MYLIP and MTAP

Number of citations of the paper that reports this interaction (PMID 12826659)
9

Data Source:
HPRD (in vitro, two hybrid)

		MYLIP	MTAP
Gene Name		myosin regulatory light chain interacting protein	methylthioadenosine phosphorylase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Phosphorylase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Movement Of Cell Or Subcellular Component Nervous System Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process	Sulfur Amino Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Polyamine Metabolic Process Nicotinamide Riboside Catabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Methylation Response To Testosterone Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs			Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5\'-Deoxy-5\'-Methylthioadenosine 5\'-Deoxy-5\'-(Methylthio)-Tubercidin
Diseases
GWAS		LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Response to statin therapy (LDL-C) ( 22331829)	Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Melanoma ( 21983787)
Protein-Protein Interactions		15 interactors: CNPY2 KDM1A LDLR LRP8 MIPOL1 MTAP MYL12B RASSF5 TSC22D4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	6 interactors: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB
Entrez ID		29116	4507
HPRD ID		17621	01134
Ensembl ID		ENSG00000007944	ENSG00000099810
Uniprot IDs		Q5TIA5 Q8WY64	B4DUC8 Q13126
PDB IDs		2YHN 2YHO	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Reelin-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Negative Regulation Of Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Response To Stimulus Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts
Tagcloud (Difference) ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts
Tagcloud (Intersection) ?