MYLIP and LDLR

Number of citations of the paper that reports this interaction (PMID 22109552)
4

Data Source:
BioGRID (unspecified method)

		MYLIP	LDLR
Gene Name		myosin regulatory light chain interacting protein	low density lipoprotein receptor
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane	Lysosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding
	Biological Process	Movement Of Cell Or Subcellular Component Nervous System Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process	Retinoid Metabolic Process Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Viral Process Intestinal Cholesterol Absorption Cholesterol Transport Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Small Molecule Metabolic Process Cholesterol Import Regulation Of Cholesterol Homeostasis
Pathways			Lipoprotein metabolism LDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs			Porfimer Alpha-D-Mannose
Diseases
GWAS		LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Response to statin therapy (LDL-C) ( 22331829)	Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109 22916037) Myocardial infarction (early onset) ( 19198609)
Protein-Protein Interactions		15 interactors: CNPY2 KDM1A LDLR LRP8 MIPOL1 MTAP MYL12B RASSF5 TSC22D4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	15 interactors: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MYLIP PCSK9 PF4 SNX17
Entrez ID		29116	3949
HPRD ID		17621	06091
Ensembl ID		ENSG00000007944	ENSG00000130164
Uniprot IDs		Q5TIA5 Q8WY64	P01130
PDB IDs		2YHN 2YHO	1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Reelin-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Negative Regulation Of Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Response To Stimulus Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Receptor-mediated Endocytosis Cholesterol Homeostasis Sterol Homeostasis Vesicle-mediated Transport Plasma Lipoprotein Particle Clearance Lipid Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Endocytosis Regulation Of Endocytosis Low-density Lipoprotein Particle Clearance Cellular Localization Steroid Metabolic Process Positive Regulation Of Endocytosis Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Establishment Of Localization In Cell Regulation Of Signal Transduction Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Alcohol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Lipid Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Beta-amyloid Clearance Positive Regulation Of Cell Differentiation Platelet Degranulation Regulation Of Low-density Lipoprotein Particle Clearance CGMP-mediated Signaling Cholesterol Catabolic Process Low-density Lipoprotein Particle Remodeling Transport Regulation Of Cell Differentiation Protein Catabolic Process Positive Regulation Of Cholesterol Storage Lipid Transport Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Lipoprotein Transport Lipid Localization Neutral Lipid Metabolic Process
Tagcloud ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Difference) ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	atresia atretic chicken cloning clusterin correlating follicle follicles granulosa heterodimer hitherto internalize intracellularly intriguing lr8 megalin migrates oocyte oocytes polyacrylamide postovulatory prime sac situations successors thereof uncovered vitellogenesis yolk
Tagcloud (Intersection) ?		ldlr