TRA2A and YTHDC1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TRA2A	YTHDC1
Description		transformer 2 alpha homolog	YTH N6-methyladenosine RNA binding protein C1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Binding MRNA Binding Protein Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing MRNA Export From Nucleus Spermatogenesis RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Primary Follicle Stage MRNA Alternative Polyadenylation
Pathways			Nuclear RNA decay
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Mean corpuscular hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		82 interacting genes: C11orf58 CDK2AP2 CDK6 CRABP1 DHX15 FOXP1 LBP MAGOHB MIR1-1 MIR1-2 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NUDT21 NXF1 PPP1CC RNPS1 SELENBP1 SRSF10 TNNT1 U2SURP UBE4B XPOT YTHDC1 YWHAG	41 interacting genes: ABL1 ADAMTS4 ANKRD28 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 KRTAP10-6 LAMC3 LAMTOR5 LZTS2 PHF19 PICK1 PLG PROSER2 RBMY1A1 RBMY1F RBMY1J RNPS1 SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		29896	91746
HPRD ID		04096	11689
Ensembl ID		ENSG00000164548	ENSG00000083896
Uniprot IDs		Q13595 Q549U1	J3QR07 Q96MU7
PDB IDs			2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7 6SYZ 6SZ1 6SZ2 6SZ3 6SZL 6SZN 6SZR 6SZT 6SZX 6SZY 6T01 6T02 6T03 6T04 6T05 6T06 6T07 6T08 6T09 6T0A 6T0C 6T0D 6T0O 6T0X 6T0Z 6T10 6T11 6T12 6WE8 6WE9 6WEA 6YKE 6YKI 6YKJ 6YKZ 6YL0 6YL8 6YL9 6YM2 6YM8 6YNI 6YNJ 6YNK 6YNL 6YNM 6YNN 6YNO 6YNP 6YOQ 6ZCM 6ZCN 6ZD9 7L4X 7L4Y 7P87 7P88 7P8A 7P8B 7P8F 7PJ7 7PJ8 7PJ9 7PJA 7PJB 7PJP 7PJQ 7PO6 8K2E 8Q2Q 8Q2R 8Q2S 8Q2T 8Q2U 8Q2V 8Q2W 8Q2X 8Q2Y 8Q31 8Q32 8Q33 8Q35 8Q37 8Q38 8Q39 8Q3A 8Q3G 8Q4M 8Q4N 8Q4P 8Q4Q 8Q4R 8Q4T 8Q4U 8Q4V 8Q4W
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Extracellular Space Regulation Of Metabolic Process Regulation Of Cell Migration Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of RNA Splicing RNA Processing Nucleic Acid Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Domain Specific Binding Non-membrane Spanning Protein Tyrosine Kinase Activity MRNA Binding RNA Binding Spliceosomal Complex RNA Metabolic Process Protein Tyrosine Kinase Activity Macromolecule Metabolic Process SH2 Domain Binding Nucleoplasm Nuclear Speck Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Positive Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Kinase Activity Positive Regulation Of MRNA Metabolic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gene Expression Phosphorylation Regulation Of RNA Metabolic Process Identical Protein Binding Ephrin Receptor Binding Nucleus Regulation Of Primary Metabolic Process Nucleolus Fc-gamma Receptor Signaling Pathway Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Actin Nucleation Activated T Cell Proliferation Ephrin Receptor Signaling Pathway
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