TRA2A and MAGOHB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRA2A	MAGOHB
Description		transformer 2 alpha homolog	mago homolog B, exon junction complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Exon-exon Junction Complex Neuronal Cell Body U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		82 interacting genes: C11orf58 CDK2AP2 CDK6 CRABP1 DHX15 FOXP1 LBP MAGOHB MIR1-1 MIR1-2 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NUDT21 NXF1 PPP1CC RNPS1 SELENBP1 SRSF10 TNNT1 U2SURP UBE4B XPOT YTHDC1 YWHAG	74 interacting genes: ADAMTSL4 AMOTL2 BEND7 C18orf54 CALCOCO2 CARD10 CCDC102B CCDC106 CCDC33 CEBPA DVL2 DVL3 EFHC2 FHL5 FXR1 GNPDA2 GOLGA2 GPANK1 HMG20A HSF2BP IHO1 IKZF1 IKZF3 INCA1 KRT40 KRT75 KRTAP1-1 KRTAP13-2 MID2 NDUFB7 PARD6B PAX7 PBX4 PKP2 PRPH PRPSAP1 PTPN21 RBAK RBM8A RBMX REL RUNDC3A SNW1 SPATA6 SPDYE4 STX11 TADA2A TCF4 TERF2 TERF2IP THAP7 TLE5 TRA2A TRA2B TRIM27 TRIM42 YWHAG ZBTB10 ZBTB42 ZFP14 ZFYVE1 ZNF19 ZNF250 ZNF398 ZNF426 ZNF438 ZNF446 ZNF449 ZNF547 ZNF566 ZNF57 ZNF620 ZNF774 ZNF835
Entrez ID		29896	55110
HPRD ID		04096	08544
Ensembl ID		ENSG00000164548	ENSG00000111196
Uniprot IDs		Q13595 Q549U1	F5H6P7 Q96A72
PDB IDs			5XJC 5YZG 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Extracellular Space Regulation Of Metabolic Process Regulation Of Cell Migration Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration	Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process Zinc Ion Binding Regulation Of Macromolecule Biosynthetic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of RNA Splicing Identical Protein Binding Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Intermediate Filament Organization Regulation Of MRNA Processing Shelterin Complex Protection From Non-homologous End Joining At Telomere Positive Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Positive Regulation Of Neuron Projection Arborization Positive Regulation Of RNA Metabolic Process Nuclear Telomere Cap Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament G-rich Strand Telomeric DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Chromosome, Telomeric Region Spliceosomal Complex Regulation Of RNA Splicing Telomere Capping Metal Ion Binding Telomere Maintenance In Response To DNA Damage
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