CPSF1 and HMOX1

Number of citations of the paper that reports this interaction (PMID 21102410)
7

Data Source:
BioGRID (unspecified method)

		CPSF1	HMOX1
Gene Name		cleavage and polyadenylation specific factor 1, 160kDa	heme oxygenase (decycling) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	MRNA 3'-UTR Binding Protein Binding	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Signal Transducer Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Small Molecule Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Homooligomerization Iron Ion Homeostasis Transmembrane Transport Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of Mature mRNA Derived from an Intronless Transcript RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Intronless Pre-mRNAs Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs			NADH Formic Acid Biliverdine Ix Alpha 12-Phenylheme Heme 2-Phenylheme Verdoheme 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: CSTF2T CSTF3 CTD GLIS2 HMOX1 IL7R MCM2 NEDD4 PAPOLA POLR2A PRRC2A REL RRAGA TAF11 TAF12 TAF13 TAF5 TAF7	10 interactors: AKT1 ASL BLVRB CCDC155 CPSF1 NOS1 POR POT1 TERF1 TUT1
Entrez ID		29894	3162
HPRD ID		05823	00782
Ensembl ID		ENSG00000071894	ENSG00000100292
Uniprot IDs		Q10570	P09601 Q6FH11
PDB IDs			1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation DNA-templated Transcription, Initiation Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Processing RNA Polyadenylation Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Gene Expression Termination Of RNA Polymerase II Transcription MRNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Transcription RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spermine Transport Transmission Of Virus Development Involved In Symbiotic Interaction Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Viral Transcription Response To Cytokine Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Viral Process	Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Arginine Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Regulation Of Telomere Maintenance Via Telomerase Reactive Oxygen Species Metabolic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Telomerase Activity MRNA Cleavage Arginine Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Monooxygenase Activity MRNA Polyadenylation Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Sodium Ion Transport RNA Polyadenylation Positive Regulation Of Oxidoreductase Activity Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Metabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Sodium Ion Transport Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Organelle Organization Negative Regulation Of Protein Processing Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Nitrate Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cellular Organofluorine Metabolic Process Positive Regulation Of DNA Strand Elongation Chromosome Localization To Nuclear Envelope Involved In Synapsis Nitric Oxide Catabolic Process Catabolic Process Regulation Of Oxidoreductase Activity MRNA 3'-end Processing Negative Regulation Of Hydrolase Activity
Tagcloud ?			alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Difference) ?			alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Intersection) ?