CPSF1

Description		cleavage and polyadenylation specific factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	MRNA Processing RNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Educational attainment ( 25201988)
Interacting Genes		58 interacting genes: CSTF2T GLIS2 HMOX1 IL7R INCA1 MCM2 MIR1-2 MIR106B MIR107 MIR122 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR29A MIR31 MIR34A MIR34B MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7 UBC
Entrez ID		29894
HPRD ID		05823
Ensembl ID		ENSG00000071894
Uniprot IDs		Q10570
PDB IDs		6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Angiogenesis Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cytokine Production Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of RNA Stability Extracellular Space Regulation Of Translation Negative Regulation Of Cell Communication
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