GTF2F1 and ARNT

Number of citations: 0 (PubMedID 8794892)
Data Source: BioGRID (pull down)

		GTF2F1	ARNT
Name		general transcription factor IIF subunit 1	aryl hydrocarbon receptor nuclear translocator
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIF Complex Cell Junction Protein-containing Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II General Transcription Initiation Factor Binding TFIIF-class Transcription Factor Complex Binding DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Phosphatase Activator Activity Protein Phosphatase Binding Protein Domain Specific Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Response To Virus Negative Regulation Of Protein Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Congenital left-sided heart lesions ( 26965164 ) Cutaneous squamous cell carcinoma ( 32041948 ) Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting glucose ( 34059833 ) Hip circumference adjusted for BMI ( 34021172 ) Melanoma ( 21983785 28212542 ) Metabolic syndrome ( 31589552 ) Platelet count ( 32888494 ) Rhegmatogenous retinal detachment ( 23585552 ) Tea consumption ( 31046077 ) Urate levels ( 23263486 )
Novel Interactors		1 novel interactors: GPX4	None recorded
Interacting Genes		34 interacting genes: ABL1 AHR AR ARNT ATF7IP BCL2L13 CCNT1 CDK9 CEBPA CFTR CSNK2A1 CTDP1 CTDSP1 DAPK1 FEZ1 FNDC3B FOS GTF2A1 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 JUN MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TRIM27	78 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLOCK CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TRIP11 TUBB2A UBE2I
Entrez ID		2962	405
HPRD ID		01803	00524
Ensembl ID		ENSG00000125651	ENSG00000143437
Uniprot IDs		P35269	A8K6P0 B0AZM1 P27540 Q53F30
PDB IDs		1F3U 1I27 1J2X 1NHA 1ONV 2K7L 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0	1X0O 2A24 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C 6X21 6X28 6X2H 6X37 6X3D 8CK3 8CK4 8CK8 8G4A 8XS6 8XS7 8XS8 8XS9 8XSA 8XSB
GO Terms Enriched among Interactors		Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Initiation Nucleoplasm Host-mediated Activation Of Viral Transcription Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nucleic Acid Metabolic Process TBP-class Protein Binding Positive Regulation Of RNA Metabolic Process DNA Binding Host-mediated Perturbation Of Viral Transcription Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MiRNA Transcription Host-mediated Perturbation Of Viral Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of Gene Expression Rhythmic Process Developmental Process Cytoplasm Cell Differentiation Regulation Of Cell Cycle Signal Transduction Animal Organ Development Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation DNA-templated Transcription Regulation Of Programmed Cell Death DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cytosol DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Developmental Process