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GTF2F1 and PSMC2
Number of citations of the paper that reports this interaction (PubMedID
11118327
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
GTF2F1
PSMC2
Description
general transcription factor IIF subunit 1
proteasome 26S subunit, ATPase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIF Complex
Cell Junction
Protein-containing Complex
Proteasome Complex
P-body
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Cytoplasmic Ribonucleoprotein Granule
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Polymerase II General Transcription Initiation Factor Binding
TFIIF-class Transcription Factor Complex Binding
DNA Binding
RNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Phosphatase Activator Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Promoter-specific Chromatin Binding
Nucleotide Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Biological Process
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Response To Virus
Negative Regulation Of Protein Binding
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Interacting Genes
34 interacting genes:
ABL1
AHR
AR
ARNT
ATF7IP
BCL2L13
CCNT1
CDK9
CEBPA
CFTR
CSNK2A1
CTDP1
CTDSP1
DAPK1
FEZ1
FNDC3B
FOS
GTF2A1
GTF2B
GTF2E1
GTF2E2
GTF2F2
GTF2H4
JUN
MAGEC1
MSX2
MYC
PARP1
PSMC2
PTN
SRF
TAF1
TAF11
TRIM27
23 interacting genes:
CDKN1A
CEP55
CNOT7
FILNC1
GTF2B
GTF2F1
GTF2H1
NDC80
NDRG1
OGT
POLR2M
PRKN
PSMC1
PSMC4
PSMD2
PSMD5
RPN1
SKIL
STUB1
SUMO4
TBP
TRAF6
TRIM5
Entrez ID
2962
5701
HPRD ID
01803
01105
Ensembl ID
ENSG00000125651
ENSG00000161057
Uniprot IDs
P35269
A0A140VK70
B7Z571
P35998
PDB IDs
1F3U
1I27
1J2X
1NHA
1ONV
2K7L
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6O9L
7EDX
7EG7
7EG8
7EG9
7EGA
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVS
7NVT
7NVU
7NVY
7NVZ
7NW0
7ZWD
7ZX7
7ZX8
8BVW
8BYQ
8BZ1
8GXQ
8GXS
8S51
8S52
8S54
8S55
8S5N
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
8WAT
8WAU
8WAV
8WAW
8WAX
8WAY
8WAZ
8WB0
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
?
Transcription By RNA Polymerase II
DNA-templated Transcription
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Initiation At RNA Polymerase II Promoter
Nucleobase-containing Compound Biosynthetic Process
Transcription Factor TFIID Complex
DNA-templated Transcription Initiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Transcription By RNA Polymerase II
RNA Metabolic Process
Nucleus
Positive Regulation Of DNA-templated Transcription Initiation
Nucleoplasm
Host-mediated Activation Of Viral Transcription
Regulation Of DNA-templated Transcription Initiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Macromolecule Biosynthetic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription Regulator Complex
Nucleic Acid Metabolic Process
TBP-class Protein Binding
Positive Regulation Of RNA Metabolic Process
DNA Binding
Host-mediated Perturbation Of Viral Transcription
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Host-mediated Activation Of Viral Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Cis-regulatory Region Binding
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Binding
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription Initiation By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of MiRNA Transcription
Host-mediated Perturbation Of Viral Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Transcription Initiation At RNA Polymerase II Promoter
Proteasome Complex
DNA-templated Transcription Initiation
Protein K63-linked Ubiquitination
Nucleus
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Transcription Factor TFIID Complex
Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Proteasome-activating Activity
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
RNA Polymerase II General Transcription Initiation Factor Binding
Protein-containing Complex
Positive Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Regulation Of Phosphorus Metabolic Process
Protein Autoubiquitination
Proteasome Regulatory Particle
Transcription Preinitiation Complex
Regulation Of Protein Ubiquitination
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Ubiquitin-ubiquitin Ligase Activity
Regulation Of Phosphorylation
DNA-templated Transcription
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Post-translational Protein Modification
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Organelle Localization
Ubiquitin-protein Transferase Activity
Positive Regulation Of Protein Ubiquitination
Proteasomal Protein Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Mitophagy
Regulation Of Primary Metabolic Process
Membraneless Organelle Assembly
Macromolecule Biosynthetic Process
Protein Polyubiquitination
DNA Damage Response
Positive Regulation Of Autophagy Of Mitochondrion
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