GTF2F1 and GTF2B

Number of citations of the paper that reports this interaction (PMID 8662660)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GTF2F1	GTF2B
Gene Name		general transcription factor IIF, polypeptide 1, 74kDa	general transcription factor IIB
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Cell Junction	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Transcription Coactivator Activity Catalytic Activity Protein Binding Transcription Factor Binding Phosphatase Activator Activity Poly(A) RNA Binding	Core Promoter Binding Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Thyroid Hormone Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Response To Virus Gene Expression Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Catalytic Activity Positive Regulation Of Viral Transcription	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Influenza Life Cycle HIV elongation arrest and recovery HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Influenza Viral RNA Transcription and Replication RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		31 interactors: ABL1 AHR AR ARNT ATF7IP CCNT1 CDK9 CSNK2A1 CTDP1 CTDSP1 FCP1 FEZ1 FOS GTF2A1 GTF2B GTF2E2 GTF2F2 GTF2H4 JUN KLF5 MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TBP TRIM27	56 interactors: ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 MYC NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POLR2E POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE
Entrez ID		2962	2959
HPRD ID		01803	08928
Ensembl ID		ENSG00000125651	ENSG00000137947
Uniprot IDs		P35269	Q00403
PDB IDs		1F3U 1I27 1J2X 1NHA 1ONV 2K7L	1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated DNA-templated Transcription, Elongation RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Viral Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Viral Process Regulation Of Viral Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cellular Component Organization Negative Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression DNA-templated Transcription, Initiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Viral Transcription Response To Organic Substance Positive Regulation Of Viral Transcription Regulation Of Viral Process Cellular Response To Organic Substance Positive Regulation Of Viral Process Metabolic Process Steroid Hormone Mediated Signaling Pathway
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?