CXCL2 and CXCR1

Number of citations: 41 (PubMedID 9260277)
Data Source: HPRD (in vivo, in vitro)

		CXCL2	CXCR1
Name		C-X-C motif chemokine ligand 2	C-X-C motif chemokine receptor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Dendritic Cell Chemotaxis Chemotaxis Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		None	Ketoprofen
GWAS		Basophil percentage of white cells ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 29403010 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 29403010 27863252 21738479 ) White blood cell types ( 21738478 )	Basophil count ( 32888494 ) Diffusing capacity of carbon monoxide ( 30694715 ) Idiopathic intracranial hypertension ( 29608535 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil count ( 29403010 ) Smooth-surface caries ( 23470693 ) White blood cell count ( 29403010 )
Novel Interactors		None recorded	1 novel interactors: TUBA4A
Interacting Genes		19 interacting genes: CCL11 CCL21 CCL28 CCL5 CCL8 CXCL11 CXCL12 CXCL14 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 EPS8 PF4 PIK3R1 PLG XCL1 XCL2	20 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C
Entrez ID		2920	3577
HPRD ID		00741	00908
Ensembl ID		ENSG00000081041	ENSG00000163464
Uniprot IDs		P19875	P25024
PDB IDs		1QNK 5OB5 8XVU 8XXH	1ILP 1ILQ 2LNL 6XMN 8IC0
GO Terms Enriched among Interactors		Chemokine Activity Leukocyte Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Chemotaxis Chemotaxis Antimicrobial Humoral Response Cell Migration Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Granulocyte Migration Cytokine Activity Humoral Immune Response Cytokine-mediated Signaling Pathway Immune System Process Immune Response Mononuclear Cell Migration Defense Response To Symbiont Defense Response To Other Organism Cell Killing Killing Of Cells Of Another Organism Neutrophil Chemotaxis Inflammatory Response CXCR Chemokine Receptor Binding Defense Response Neutrophil Migration Response To Other Organism Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway CCR Chemokine Receptor Binding Chemokine Receptor Binding Extracellular Space Dendritic Cell Migration Extracellular Region Signal Transduction Cell-cell Signaling Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stress Dendritic Cell Chemotaxis Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Eosinophil Chemotaxis	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Antimicrobial Humoral Response Granulocyte Migration CXCR Chemokine Receptor Binding Chemotaxis Cytokine Activity Locomotion Inflammatory Response Myeloid Leukocyte Migration Leukocyte Chemotaxis Humoral Immune Response Cell Migration Cell Motility Leukocyte Migration Killing Of Cells Of Another Organism Guanyl Nucleotide Binding G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Cell Killing Neutrophil Activation Heterotrimeric G-protein Complex Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Defense Response Defense Response To Symbiont Defense Response To Other Organism Response To Molecule Of Bacterial Origin Immune Response Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide GTP Binding Extracellular Region Cellular Response To Molecule Of Bacterial Origin G Protein-coupled Receptor Binding Protein Polymerization Cell Division Extracellular Space Response To Other Organism Microtubule Polymerization G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Lipopolysaccharide Myeloid Leukocyte Activation D-glucose Transmembrane Transport Response To External Biotic Stimulus