CXCL2 and CXCR1

Number of citations of the paper that reports this interaction (PMID 9260277)
6

Data Source:
HPRD (in vitro, in vivo)

		CXCL2	CXCR1
Gene Name		chemokine (C-X-C motif) ligand 2	chemokine (C-X-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Interleukin-8 Receptor Activity G-protein Coupled Receptor Activity Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Response To Molecule Of Bacterial Origin Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cell Chemotaxis Chemokine-mediated Signaling Pathway	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) White blood cell count ( 21738479) White blood cell types ( 21738478)	Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		5 interactors: CXCR1 CXCR2 EPS8 PIK3R1 PLG	16 interactors: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C
Entrez ID		2920	3577
HPRD ID		00741	00908
Ensembl ID		ENSG00000081041	ENSG00000163464
Uniprot IDs		P19875	P25024
PDB IDs		1QNK	1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Dendritic Cell Migration Interleukin-8-mediated Signaling Pathway Cell Migration Cell Motility Locomotion Movement Of Cell Or Subcellular Component Dendritic Cell Chemotaxis Immune System Process Receptor Internalization Negative Regulation Of Cell-substrate Adhesion Chemokine-mediated Signaling Pathway Vesicle-mediated Transport Receptor Metabolic Process Leukocyte Chemotaxis Endocytosis Negative Regulation Of Neutrophil Apoptotic Process NFAT Protein Import Into Nucleus Cell Activation Cellular Homeostasis Transcription Factor Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Cell Chemotaxis ERBB Signaling Pathway Response To Organic Substance Mononuclear Cell Migration Actin Polymerization-dependent Cell Motility Platelet Activation Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Acute Inflammatory Response To Antigenic Stimulus Exit From Mitosis Cell Surface Receptor Signaling Pathway Defense Response Homeostatic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Behavioral Response To Ethanol Positive Regulation Of Vascular Permeability Response To Stress Positive Regulation Of Cellular Component Movement Metanephric Tubule Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Receptor-mediated Endocytosis Negative Regulation Of Immune System Process Regulation Of Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Inflammatory Response Response To Cytokine Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Bacterium Locomotion Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Organic Substance Response To Organic Substance Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Movement Of Cell Or Subcellular Component Response To Other Organism Response To Biotic Stimulus Response To Lipid Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?		chemokine chemokines neutrophil