CXCL2 and CXCR2

Number of citations of the paper that reports this interaction (PMID 8702798)
57

Data Source:
HPRD (in vitro, in vivo)

		CXCL2	CXCR2
Gene Name		chemokine (C-X-C motif) ligand 2	chemokine (C-X-C motif) receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule
	Molecular Function	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Response To Molecule Of Bacterial Origin Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cell Chemotaxis Chemokine-mediated Signaling Pathway	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) White blood cell count ( 21738479) White blood cell types ( 21738478)	Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		5 interactors: CXCR1 CXCR2 EPS8 PIK3R1 PLG	21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		2920	3579
HPRD ID		00741	00907
Ensembl ID		ENSG00000081041	ENSG00000180871
Uniprot IDs		P19875	P25025 Q53PC4
PDB IDs		1QNK
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Dendritic Cell Migration Interleukin-8-mediated Signaling Pathway Cell Migration Cell Motility Locomotion Movement Of Cell Or Subcellular Component Dendritic Cell Chemotaxis Immune System Process Receptor Internalization Negative Regulation Of Cell-substrate Adhesion Chemokine-mediated Signaling Pathway Vesicle-mediated Transport Receptor Metabolic Process Leukocyte Chemotaxis Endocytosis Negative Regulation Of Neutrophil Apoptotic Process NFAT Protein Import Into Nucleus Cell Activation Cellular Homeostasis Transcription Factor Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Cell Chemotaxis ERBB Signaling Pathway Response To Organic Substance Mononuclear Cell Migration Actin Polymerization-dependent Cell Motility Platelet Activation Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Acute Inflammatory Response To Antigenic Stimulus Exit From Mitosis Cell Surface Receptor Signaling Pathway Defense Response Homeostatic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Behavioral Response To Ethanol Positive Regulation Of Vascular Permeability Response To Stress Positive Regulation Of Cellular Component Movement Metanephric Tubule Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Receptor-mediated Endocytosis Negative Regulation Of Immune System Process Regulation Of Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		act1 alpha blot ccl20 changed cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf	ab attenuating chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?		chemokine chemokines neutrophil