CXCL2

Gene Name		chemokine (C-X-C motif) ligand 2
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Response To Molecule Of Bacterial Origin Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) White blood cell count ( 21738479) White blood cell types ( 21738478)
Protein-protein Interactions		5 interactors: CXCR1 CXCR2 EPS8 PIK3R1 PLG
Entrez ID		2920
HPRD ID		00741
Ensembl ID		ENSG00000081041
Uniprot IDs		P19875
PDB IDs		1QNK
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Dendritic Cell Migration Interleukin-8-mediated Signaling Pathway Cell Migration Cell Motility Locomotion Movement Of Cell Or Subcellular Component Dendritic Cell Chemotaxis Immune System Process Receptor Internalization Negative Regulation Of Cell-substrate Adhesion Chemokine-mediated Signaling Pathway Vesicle-mediated Transport Receptor Metabolic Process Leukocyte Chemotaxis Endocytosis Negative Regulation Of Neutrophil Apoptotic Process NFAT Protein Import Into Nucleus Cell Activation Cellular Homeostasis Transcription Factor Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Cell Chemotaxis ERBB Signaling Pathway Response To Organic Substance Mononuclear Cell Migration Actin Polymerization-dependent Cell Motility Platelet Activation Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Acute Inflammatory Response To Antigenic Stimulus Exit From Mitosis Cell Surface Receptor Signaling Pathway Defense Response Homeostatic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Behavioral Response To Ethanol Positive Regulation Of Vascular Permeability Response To Stress Positive Regulation Of Cellular Component Movement Metanephric Tubule Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Receptor-mediated Endocytosis Negative Regulation Of Immune System Process Regulation Of Cell-cell Adhesion
Tagcloud ?		act1 alpha blot ccl20 changed chemokine chemokines cultured cxcl1 cxcl5 cxcl6 declined ht il intestinal knockdown line neutrophil obvious obviously p38 played proinflammatory promoted stable synergistic th th17 tnf