TBK1 and CALCOCO2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down, pull down)

		TBK1	CALCOCO2
Gene Name		TANK-binding kinase 1	calcium binding and coiled-coil domain 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphoprotein Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium Defense Response To Virus	Viral Process Response To Interferon-gamma
Pathways		Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade STING mediated induction of host immune responses TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP	143 interactors: ABLIM1 ADSL AES AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 BAHD1 BCL6B BEX2 C20orf195 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYO6 NAA10 NDN NFU1 ORC5 PAPD4 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TAX1BP1 TBC1D22B TBK1 TBRG4 TCEB3B TCL1A TEKT3 TP53RK TRAF2 TRAF4 TRAF6 UBAC2 UBB UBC VARS VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638
Entrez ID		29110	10241
HPRD ID		05322	06846
Ensembl ID		ENSG00000183735	ENSG00000136436
Uniprot IDs		Q9UHD2	Q13137
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ	3VVV 3VVW 4GXL 4HAN
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Defense Response Immune System Process Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Intracellular Receptor Signaling Pathway Signaling Response To Stimulus I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Regulation Of Interferon-beta Production Response To Other Organism Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Response To External Stimulus Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To DsRNA Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signaling	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production MRNA Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter JNK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Modification By Small Protein Conjugation Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Type I Interferon Production Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity G1/S Transition Of Mitotic Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Difference) ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	ad astrocytes atg atgs autophagic autophagy avs beneficial brains clear clearance enhancement expected facilitating flux hippocampal impairment lc3 localized microglia mouse ndp52 p62 phosphorylated plaques reflecting sqstm1 tau vesicles
Tagcloud (Intersection) ?