TBK1 and TXLNA

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		TBK1	TXLNA
Gene Name		TANK-binding kinase 1	taxilin alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane	Extracellular Region Cytoplasm Membrane
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphoprotein Binding	Cytokine Activity Protein Binding Syntaxin Binding High Molecular Weight B Cell Growth Factor Receptor Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium Defense Response To Virus	Exocytosis Cell Proliferation B Cell Activation
Pathways		Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade STING mediated induction of host immune responses TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP	53 interactors: AZI2 BRCA1 BTF3 BTF3L4 CCDC136 CCDC53 CCDC67 CCHCR1 CDR2 CEP44 CEP57L1 CEP63 DTNB EIF4ENIF1 GOLGA2 GORASP2 HAUS3 HYPK IKBKG KANK2 KRT13 KRT15 KRT20 KRT31 KRT38 KRT40 LCA5 MBIP MED4 MEOX1 MEOX2 NACA NDC80 NMI NSMCE2 NUP62 PPFIA1 RCOR3 RINT1 SMARCE1 SPERT STMN2 STX1A STX3 STX4 TBK1 TCL1A TFIP11 TNIP1 TP53BP2 TXLNB USHBP1 VPS52
Entrez ID		29110	200081
HPRD ID		05322	09408
Ensembl ID		ENSG00000183735	ENSG00000084652
Uniprot IDs		Q9UHD2	P40222
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Defense Response Immune System Process Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Intracellular Receptor Signaling Pathway Signaling Response To Stimulus I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Regulation Of Interferon-beta Production Response To Other Organism Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Response To External Stimulus Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To DsRNA Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signaling	Synaptic Vesicle Fusion To Presynaptic Membrane Dendritic Cell Proliferation Organelle Organization Protein Localization Cell Cycle Protein Transport Establishment Of Protein Localization Mitotic Cell Cycle Neurotransmitter Secretion Somite Specification Positive Regulation Of Protein Localization To Cell Surface Regulation Of Neurotransmitter Levels Vesicle Fusion Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis I-kappaB Kinase/NF-kappaB Signaling Neurotransmitter Transport Establishment Of Organelle Localization Microtubule-based Process Type I Interferon Production Developmental Process Organelle Fusion Centriole Assembly Positive Regulation Of Transcription, DNA-templated Vesicle Docking Establishment Of Vesicle Localization Establishment Of Localization In Cell Segment Specification Interferon-gamma Production Vesicle Localization Cellular Localization Centrosome Organization Membrane Docking Regulation Of Protein Localization To Cell Surface Regulation Of I-kappaB Kinase/NF-kappaB Signaling Organelle Localization Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Glutamate Secretion Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Synaptic Vesicle Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Spindle Organization Membrane Fusion Pattern Recognition Receptor Signaling Pathway
Tagcloud ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers
Tagcloud (Difference) ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers
Tagcloud (Intersection) ?