CALR and VWF

Number of citations of the paper that reports this interaction (PMID 10887119)
13

Data Source:
HPRD (in vivo)

		CALR	VWF
Gene Name		calreticulin	von Willebrand factor
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Sarcoplasmic Reticulum Lumen MHC Class I Peptide Loading Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome
	Molecular Function	Complement Component C1q Binding Glycoprotein Binding DNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Poly(A) RNA Binding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein N-linked Glycosylation Via Asparagine Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Regulation Of Meiosis Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Chaperone-mediated Protein Folding Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Cell Chemotaxis	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Scavenging by Class F Receptors Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Scavenging by Class A Receptors Assembly of Viral Components at the Budding Site ATF6-alpha activates chaperones Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ATF6-alpha activates chaperone genes Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Antihemophilic Factor
Diseases
GWAS		Red blood cell traits ( 23222517)	Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		39 interactors: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 SCARF1 SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TSHR UPF2 VWF	16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		811	7450
HPRD ID		00169	01906
Ensembl ID		ENSG00000179218	ENSG00000110799
Uniprot IDs		P27797	P04275
PDB IDs		2CLR 3DOW 3POS 3POW	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU
Enriched GO Terms of Interacting Partners?		Response To Stimulus Response To Stress Platelet Degranulation Blood Coagulation Hemostasis Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Wound Healing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cell Activation Response To Wounding Platelet Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Exocytosis Response To External Stimulus Cellular Response To Stimulus Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I System Development Secretion By Cell Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Cell Communication Immune Response Behavior Positive Regulation Of Leukocyte Mediated Cytotoxicity Transport Secretion Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Protection From Natural Killer Cell Mediated Cytotoxicity Signaling Multicellular Organismal Development Signal Transduction Negative Regulation Of Signaling Cell Adhesion Response To Hormone Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Anatomical Structure Development Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Organic Substance	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction
Tagcloud ?		administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand	afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite
Tagcloud (Difference) ?		administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand	afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite
Tagcloud (Intersection) ?