CALR and ITIH1

Data Source: HiPPIP (Novel)

		CALR	ITIH1
Name		calreticulin	inter-alpha-trypsin inhibitor heavy chain 1
Structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion External Side Of Plasma Membrane Cell Surface Endomembrane System Membrane Sarcoplasmic Reticulum Phagocytic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Cytolytic Granule Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Extracellular Exosome Endocytic Vesicle Lumen Lumenal Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Metal Ion Binding Nuclear Androgen Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Molecular Sequestering Activity	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of DNA-templated Transcription Protein Folding Protein Export From Nucleus Intracellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ERAD Pathway Regulation Of Meiotic Nuclear Division Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Protein Maturation Cardiac Muscle Cell Differentiation Cellular Response To Electrical Stimulus Cellular Response To Lithium Ion Cellular Senescence Cellular Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Peptide Response To Glycoside Response To Biphenyl Positive Regulation Of Dendritic Cell Chemotaxis	Hyaluronan Metabolic Process
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC	None
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Clozapine-induced agranulocytosis ( 25187353 ) Estimated glomerular filtration rate ( 31152163 ) Platelet count ( 32888494 ) Red blood cell traits ( 23222517 )	A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 34002096 33263727 31043756 19416921 ) Body mass index ( 25673413 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cortical surface area (MOSTest) ( 32665545 ) General cognitive ability ( 29844566 ) Glaucoma (primary open-angle) ( 25173105 ) Osteoarthritis (hip) ( 30374069 ) Pulse pressure ( 30578418 ) Schizophrenia ( 29483656 25056061 23974872 ) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Novel Interactors		3 novel interactors: ICAM1 ICAM3 ITIH1	5 novel interactors: ARF4 ARIH2 CALR PHAX RBM15B
Interacting Genes		50 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDE4B PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TSHR UBE3A UPF2 VWF	3 interacting genes: HSP90AA1 PIK3CA SOX4
Entrez ID		811	3697
HPRD ID		00169	00927
Ensembl ID		ENSG00000179218	ENSG00000055957
Uniprot IDs		P27797 V9HW88	B7Z8B6 P19827
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR	6FPY 6FPZ
GO Terms Enriched among Interactors		Cell Surface Integrin Binding External Side Of Plasma Membrane Platelet Alpha Granule Cell Adhesion Endoplasmic Reticulum Lumen Antigen Processing And Presentation Of Endogenous Antigen Cell-cell Adhesion Platelet Alpha Granule Lumen Extracellular Space Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune System Process Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Regulation Of Extrinsic Apoptotic Signaling Pathway Extracellular Exosome Antibacterial Humoral Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Immune System Process MHC Class I Peptide Loading Complex Positive Regulation Of Cell Killing MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Positive Regulation Of Gene Expression Response To Hormone Reproductive Behavior Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Tapasin-ERp57 Complex Positive Regulation Of Endocytosis Regulation Of T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Platelet Aggregation Negative Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor Production Blood Coagulation Cellular Response To Amyloid-beta Apolipoprotein Binding Coagulation Signaling Receptor Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Tumor Necrosis Factor Production Heparan Sulfate Proteoglycan Binding	Regulation Of Cell Projection Assembly Regulation Of Apoptotic Process Intracellular Transport Nuclear Export Nuclear Transport Nucleocytoplasmic Transport Protein Stabilization Endocytic Vesicle Lumen MRNA Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Programmed Cell Death Cellular Localization Establishment Of Localization In Cell Regulation Of Lamellipodium Organization Protein Folding Chaperone Positive Regulation Of Establishment Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Glucose Stimulus CTP Binding DATP Binding Regulation Of Protein Localization Cellular Response To Virus Regulation Of Protein Stability Cellular Response To Carbohydrate Stimulus ERBB Signaling Pathway Response To Virus RNA Export From Nucleus Striated Muscle Contraction Regulation Of Gene Expression Positive Regulation Of Immune System Process Intracellular Glucose Homeostasis Regulation Of Macromolecule Biosynthetic Process Protein Transport Phospholipase D Activator Activity Positive Regulation Of Protein Localization Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Unfolded Protein Binding Regulation Of Organelle Organization Response To Biphenyl Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rho GDP-dissociation Inhibitor Binding Response To Butyrate Cellular Response To Hydrostatic Pressure Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Response To Glucose