CALR and NKX2-1

Number of citations of the paper that reports this interaction (PubMedID 9988700)
0

Data Source:
HPRD (in vivo)

		CALR	NKX2-1
Description		calreticulin	NK2 homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion External Side Of Plasma Membrane Cell Surface Endomembrane System Membrane Sarcoplasmic Reticulum Phagocytic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Cytolytic Granule Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Extracellular Exosome Endocytic Vesicle Lumen Lumenal Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Metal Ion Binding Nuclear Androgen Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Molecular Sequestering Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of DNA-templated Transcription Protein Folding Protein Export From Nucleus Intracellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ERAD Pathway Regulation Of Meiotic Nuclear Division Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Protein Maturation Cardiac Muscle Cell Differentiation Cellular Response To Electrical Stimulus Cellular Response To Lithium Ion Cellular Senescence Cellular Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Peptide Response To Glycoside Response To Biphenyl Positive Regulation Of Dendritic Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Pattern Specification Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Hypothalamus Development Forebrain Neuron Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex Neuron Differentiation Pituitary Gland Development Telencephalon Cell Migration Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation GABAergic Neuron Differentiation Interneuron Migration
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases			Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)	Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)
Interacting Genes		50 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDE4B PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TSHR UBE3A UPF2 VWF	15 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1
Entrez ID		811	7080
HPRD ID		00169	02798
Ensembl ID		ENSG00000179218	ENSG00000136352
Uniprot IDs		P27797 V9HW88	P43699
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR
Enriched GO Terms of Interacting Partners?		Cell Surface Integrin Binding External Side Of Plasma Membrane Platelet Alpha Granule Cell Adhesion Endoplasmic Reticulum Lumen Antigen Processing And Presentation Of Endogenous Antigen Cell-cell Adhesion Platelet Alpha Granule Lumen Extracellular Space Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune System Process Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Regulation Of Extrinsic Apoptotic Signaling Pathway Extracellular Exosome Antibacterial Humoral Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Immune System Process MHC Class I Peptide Loading Complex Positive Regulation Of Cell Killing MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Positive Regulation Of Gene Expression Response To Hormone Reproductive Behavior Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Tapasin-ERp57 Complex Positive Regulation Of Endocytosis Regulation Of T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Platelet Aggregation Negative Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor Production Blood Coagulation Cellular Response To Amyloid-beta Apolipoprotein Binding Coagulation Signaling Receptor Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Tumor Necrosis Factor Production Heparan Sulfate Proteoglycan Binding	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Cellular Response To Hormone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Estradiol Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Transcription Coregulator Activity Anatomical Structure Morphogenesis Chromatin Gland Development Chromatin Binding Transcription Coactivator Binding Protein-containing Complex Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Intracellular Signal Transduction Response To Hormone Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity DNA-templated Transcription Lung Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cell Differentiation Thyroid Gland Development
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