MED4 and PUM2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)

		MED4	PUM2
Gene Name		mediator complex subunit 4	pumilio RNA-binding family member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex	Cytoplasm Cytoplasmic Stress Granule Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated	Regulation Of Translation Stress Granule Assembly
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1	8 interactors: AURKA DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 NANOS1
Entrez ID		29079	23369
HPRD ID		16145	09527
Ensembl ID		ENSG00000136146	ENSG00000055917
Uniprot IDs		Q9NPJ6	B7ZL34 Q8TB72
PDB IDs			3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process	Reproduction Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translational Initiation Spermatogenesis Male Gamete Generation Gamete Generation Female Meiotic Division Sexual Reproduction Regulation Of Translation Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Translational Initiation Positive Regulation Of Translation Female Meiosis II Negative Regulation Of Spindle Checkpoint Single Organism Reproductive Process Reproductive Process Positive Regulation Of Cellular Metabolic Process Spindle Assembly Involved In Female Meiosis I Positive Regulation Of Cell Division Spindle Assembly Involved In Meiosis Spindle Stabilization Meiotic Nuclear Division Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Meiotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oocyte Maturation Meiotic Spindle Organization Regulation Of Cell Division Mitotic Centrosome Separation Protein Localization To Centrosome Female Meiosis I Regulation Of Protein Metabolic Process Positive Regulation Of Oocyte Development Centrosome Separation Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoskeleton Histone-serine Phosphorylation Positive Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Metabolic Process Regulation Of Spindle Checkpoint Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Organelle Organization
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