PUM2 and DAZ1

Number of citations of the paper that reports this interaction (PubMedID 12511597)
35

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PUM2	DAZ1
Description		pumilio RNA binding family member 2	deleted in azoospermia 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing	Spermatogenesis Cell Differentiation Positive Regulation Of Translational Initiation 3'-UTR-mediated MRNA Stabilization
Pathways		Neddylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1	10 interacting genes: BOLL DAZAP1 DAZAP2 DAZL DYNLL1 DZIP1 DZIP1L DZIP3 PUM2 QKI
Entrez ID		23369	1617
HPRD ID		09527	15958
Ensembl ID		ENSG00000055917	ENSG00000188120
Uniprot IDs		B7ZL34 Q8TB72	A0A140VJH5 Q9NQZ3
PDB IDs		3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization	MRNA 3'-UTR Binding Regulation Of MRNA Metabolic Process Organelle Assembly Stress Granule Assembly Regulation Of MRNA Stability Germ Cell Development Developmental Process Involved In Reproduction Regulation Of RNA Stability MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of RNA Catabolic Process Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Translation Activator Activity Reproductive Process 3'-UTR-mediated MRNA Stabilization Regulation Of Translation Positive Regulation Of MRNA Metabolic Process RNA Binding Male Gamete Generation Spermatogenesis Organelle Organization Cytoplasm Gamete Generation MiRNA Binding Nucleic Acid Binding Post-transcriptional Regulation Of Gene Expression Motile Cilium Assembly Positive Regulation Of Translational Initiation Cilium Assembly Membraneless Organelle Assembly Cilium Organization Internal N(7)-methylguanine-containing RNA Reader Activity Protein Localization To Cilium Pumilio-response Element Binding Female Meiosis II Cell Development Negative Regulation Of Catabolic Process Cell Projection Assembly Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Cellular Component Assembly Plasma Membrane Bounded Cell Projection Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Smoothened Signaling Pathway BBSome Binding Protein-containing Complex Localization To Centriolar Satellite Positive Regulation Of Sprouting Of Injured Axon Regulation Of Nucleobase-containing Compound Metabolic Process
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