MED4 and ATF7IP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED4	ATF7IP2
Description		mediator complex subunit 4	activating transcription factor 7 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleus Transcription Regulator Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding	Transcription Coregulator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of DNA-templated Transcription
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Copper levels ( 26025379) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment ( 20195266)
Interacting Genes		41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CEBPA CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 ITSN1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TNFAIP8L1 USHBP1 WDTC1 WWP2	7 interacting genes: FSD2 MAP1LC3A MBD1 MED4 NUP62 SETDB1 SP1
Entrez ID		29079	80063
HPRD ID		16145	16517
Ensembl ID		ENSG00000136146	ENSG00000166669
Uniprot IDs		Q9NPJ6	Q5U623
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex Kinetochore Centrosome Regulation Of DNA-templated Transcription Initiation Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Nucleosome Disassembly Regulation Of Embryonic Development	DNA Methylation-dependent Constitutive Heterochromatin Formation Constitutive Heterochromatin Formation Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Double-stranded Methylated DNA Binding Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Starvation Response To Wortmannin Cellular Response To Zinc Ion Starvation Histone H3K9 Trimethyltransferase Activity Histone H3K9 Monomethyltransferase Activity PTB Domain Binding Phospholipid Binding Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Response To Iron(II) Ion Cellular Response To Oxygen-glucose Deprivation
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