MED4 and WDTC1

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)

		MED4	WDTC1
Gene Name		mediator complex subunit 4	WD and tetratricopeptide repeats 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Enzyme Inhibitor Activity Protein Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Glucose Metabolic Process Regulation Of Cell Size Protein Ubiquitination Cellular Response To Insulin Stimulus Multicellular Organism Growth Negative Regulation Of Catalytic Activity Negative Regulation Of Fatty Acid Biosynthetic Process Cellular Chemical Homeostasis
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1	3 interactors: DDB1 MED23 MED4
Entrez ID		29079	23038
HPRD ID		16145	10307
Ensembl ID		ENSG00000136146	ENSG00000142784
Uniprot IDs		Q9NPJ6	Q8N5D0
PDB IDs			3I7N
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation By Virus Of Viral Protein Levels In Host Cell UV-damage Excision Repair Positive Regulation Of Viral Release From Host Cell Histone H2A Monoubiquitination Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Transcription From RNA Polymerase II Promoter Interaction With Symbiont Histone Ubiquitination Androgen Receptor Signaling Pathway Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process
Tagcloud ?			a8 abcc5 acvr2 biallelic crcs driver frameshift g8 glyr1 harbored intronic know microsatellite mismatch mononucleotide msh3 msi or51e2 passengers repeats rock1 suppressors t8 t9 tceb3 tgfbr2 tumourigenesis unbiased whenever
Tagcloud (Difference) ?			a8 abcc5 acvr2 biallelic crcs driver frameshift g8 glyr1 harbored intronic know microsatellite mismatch mononucleotide msh3 msi or51e2 passengers repeats rock1 suppressors t8 t9 tceb3 tgfbr2 tumourigenesis unbiased whenever
Tagcloud (Intersection) ?