MED4 and LRRFIP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MED4	LRRFIP1
Gene Name		mediator complex subunit 4	leucine rich repeat (in FLII) interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex	Cellular_component Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Biological_process Positive Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Signaling by FGFR in disease Cytosolic sensors of pathogen-associated DNA LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants Innate Immune System
Drugs
Diseases
GWAS			Adiposity ( 22739583)
Protein-Protein Interactions		36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1	3 interactors: CEP44 FLII MED4
Entrez ID		29079	9208
HPRD ID		16145	04460
Ensembl ID		ENSG00000136146	ENSG00000124831
Uniprot IDs		Q9NPJ6	B4DPC0 Q32MZ4
PDB IDs			4H22
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?			abat accuracy biomarkers bisulfite cloning dapp1 diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Difference) ?			abat accuracy biomarkers bisulfite cloning dapp1 diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Intersection) ?