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MED4 and PCBD2
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
MED4
PCBD2
Gene Name
mediator complex subunit 4
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mediator Complex
Cellular_component
Nucleus
Mitochondrion
Molecular Function
RNA Polymerase II Transcription Cofactor Activity
Transcription Cofactor Activity
Receptor Activity
Protein Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Vitamin D Receptor Binding
Thyroid Hormone Receptor Binding
Phenylalanine 4-monooxygenase Activity
Protein Binding
4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Intracellular Steroid Hormone Receptor Signaling Pathway
Androgen Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Tetrahydrobiopterin Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Protein Homotetramerization
Protein Heterooligomerization
Oxidation-reduction Process
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Bulimia nervosa (
23568457
)
Colorectal cancer (
23263487
)
Height (
18391951
)
Protein-Protein Interactions
36 interactors:
AES
AMOT
AP2M1
ATF7IP
C1orf216
CCDC101
CCDC146
CCHCR1
CTDP1
CTNNBL1
FAM13C
FOXJ3
FRMD6
FTCD
HAUS1
IFT20
KIFC3
LRRFIP1
MAB21L3
MCRS1
MED13
MED25
MED30
MED9
NDC80
NDE1
PCBD2
PUM2
SDCBP
SMARCD1
SMARCE1
SSX3
TNFAIP8
TXLNA
USHBP1
WDTC1
31 interactors:
AATF
APP
ASCC2
BRF1
C1D
CDC5L
CENPK
CHAF1A
GTF2E1
HES4
IRF2BP1
KCNIP3
MAGEA11
MED21
MED30
MED4
MED7
MET
PBXIP1
PCBD1
PHF14
PML
RUNX1T1
SNW1
SSX3
SSX5
STAT3
TAL2
TGIF2LY
XBP1
ZZZ3
Entrez ID
29079
84105
HPRD ID
16145
17824
Ensembl ID
ENSG00000136146
Uniprot IDs
Q9NPJ6
Q9H0N5
PDB IDs
4C45
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Process
Regulation Of Nitrogen Compound Metabolic Process
Gene Expression
Nucleosome Disassembly
Cellular Protein Localization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Establishment Of Cell Polarity
Cellular Localization
Cellular Nitrogen Compound Metabolic Process
Mitotic Nuclear Division
Centrosome Localization
Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Establishment Of Mitotic Spindle Orientation
Androgen Receptor Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Mediator Complex Assembly
Opsin Transport
Regulation Of Cellular Process
Establishment Of Mitotic Spindle Localization
Establishment Of Spindle Orientation
Nitrogen Compound Metabolic Process
Chromosome Organization
Establishment Or Maintenance Of Cell Polarity
Chromatin Organization
Cell Division
Protein Localization
Negative Regulation Of Transcription, DNA-templated
Movement Of Cell Or Subcellular Component
Spindle Localization
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Microtubule-based Process
Pteridine-containing Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cytoskeleton Organization
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
RNA Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Cellular Process
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
DNA-templated Transcription, Initiation
Positive Regulation Of Transcription, DNA-templated
Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Apoptotic Process
Negative Regulation Of Gene Expression
Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Cell Death
Death
Stem Cell Maintenance
Transcription From RNA Polymerase II Promoter
Cell Differentiation
Positive Regulation Of Histone Modification
Negative Regulation Of Cell Differentiation
Stem Cell Development
Developmental Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Differentiation
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Tagcloud (Intersection)
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