PUM2 and MIR92A2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PUM2	MIR92A2
Description		pumilio RNA binding family member 2	microRNA 92a-2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse	RISC Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Neddylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1	88 interacting genes: ADARB1 AIMP2 AQR C1QBP CELF1 CPSF1 CPSF2 CPSF3 CPSF4 CSTF1 CSTF2 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FIP1L1 FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBM14 RBM4 RBMS1 RBMS2 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2B TRIM25 UPF1 UTP20 WDR33 YBX1 YBX3 ZC3H7A ZNF346
Entrez ID		23369	407049
HPRD ID		09527
Ensembl ID		ENSG00000055917	ENSG00000284538
Uniprot IDs		B7ZL34 Q8TB72
PDB IDs		3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization	RNA Binding RNA Processing RNA Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Nucleus MRNA Binding Nucleoplasm Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA Binding Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA Cleavage And Polyadenylation Specificity Factor Complex Regulation Of MRNA Processing Regulation Of RNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation Regulation Of MRNA Stability Ligase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA 3'-end Processing MRNA Stabilization Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process MiRNA Processing Positive Regulation Of Gene Expression CRD-mediated MRNA Stabilization Nucleolus Regulation Of Gene Expression MRNA 5'-UTR Binding
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