NKX2-1 and FOXA1

Number of citations of the paper that reports this interaction (PubMedID 17220277)
32

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NKX2-1	FOXA1
Description		NK2 homeobox 1	forkhead box A1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Microvillus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Pattern Specification Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Hypothalamus Development Forebrain Neuron Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex Neuron Differentiation Pituitary Gland Development Telencephalon Cell Migration Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation GABAergic Neuron Differentiation Interneuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Smoothened Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Cell Differentiation Neuron Differentiation Lung Development Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Tube Morphogenesis Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Lung Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Alveolar Secondary Septum Development Connective Tissue Development Dopaminergic Neuron Differentiation Respiratory Basal Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Estrogen-dependent gene expression Formation of axial mesoderm
Drugs
Diseases		Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS		Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergy ( 27182965) Chromium levels ( 26025379) Coronary artery aneurysm in Kawasaki disease ( 26434682) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Intraocular pressure ( 29617998) Periodontitis (CDC/AAP) ( 24024966) Self-reported allergy ( 23817569) Tonsillectomy ( 27182965 28928442)
Interacting Genes		15 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1	6 interacting genes: AR H3-4 NKX2-1 ONECUT1 SEZ6L2 TLE1
Entrez ID		7080	3169
HPRD ID		02798	03801
Ensembl ID		ENSG00000136352	ENSG00000129514
Uniprot IDs		P43699	P55317
PDB IDs			7VOX 8VFY 8VFZ 8VG1 8VG2
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Cellular Response To Hormone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Estradiol Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Transcription Coregulator Activity Anatomical Structure Morphogenesis Chromatin Gland Development Chromatin Binding Transcription Coactivator Binding Protein-containing Complex Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Intracellular Signal Transduction Response To Hormone Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity DNA-templated Transcription Lung Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cell Differentiation Thyroid Gland Development	Leydig Cell Differentiation Developmental Induction Endoderm Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Epithelial Cell Differentiation Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Pancreatic D Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Globus Pallidus Development Club Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Spermatogonial Cell Division Androgen Binding DNA-binding Transcription Factor Activity Pancreatic A Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Cell Fate Commitment RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Prostatic Bud Formation Locomotory Behavior Lung Saccule Development RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Type II Pneumocyte Differentiation DNA Replication-dependent Chromatin Assembly Forebrain Neuron Fate Commitment Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Type B Pancreatic Cell Differentiation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Regulator Complex Estrogen Response Element Binding Cerebellar Purkinje Cell Layer Development Transcription Cis-regulatory Region Binding Genitalia Morphogenesis
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