NKX2-1 and PAX8

Number of citations of the paper that reports this interaction (PubMedID 12441357)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NKX2-1	PAX8
Description		NK2 homeobox 1	paired box 8
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Pattern Specification Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Hypothalamus Development Forebrain Neuron Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex Neuron Differentiation Pituitary Gland Development Telencephalon Cell Migration Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation GABAergic Neuron Differentiation Interneuron Migration	Urogenital System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Sensory Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development S-shaped Body Morphogenesis Kidney Epithelium Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways			Formation of intermediate mesoderm Formation of the nephric duct
Drugs
Diseases		Choreoathetosis, hypothyroidism, and neonatal respiratory distress	Congenital nongoitrous hypothyroidism (CHNG) Thyroid cancer
GWAS		Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)	Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Language functional connectivity ( 34929384) Lymphocyte count ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		15 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1	24 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HNF1B HOXC8 HOXC9 ID2 LONRF1 NFIC NFIX NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 WBP2
Entrez ID		7080	7849
HPRD ID		02798	01335
Ensembl ID		ENSG00000136352	ENSG00000125618
Uniprot IDs		P43699	Q06710 R9W7C9
PDB IDs			2K27
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Cellular Response To Hormone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Estradiol Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Transcription Coregulator Activity Anatomical Structure Morphogenesis Chromatin Gland Development Chromatin Binding Transcription Coactivator Binding Protein-containing Complex Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Intracellular Signal Transduction Response To Hormone Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity DNA-templated Transcription Lung Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cell Differentiation Thyroid Gland Development	Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis Regulation Of Primary Metabolic Process Chromatin Pattern Specification Process Positive Regulation Of Metabolic Process Regionalization Anterior/posterior Pattern Specification Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thigmotaxis Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Endoderm Development Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Organ Morphogenesis DNA-binding Transcription Factor Activity Gland Development Mesonephric Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Mesonephric Epithelium Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Tube Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Kidney Epithelium Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Virus Developmental Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Differentiation Response To Virus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding
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