LTB4R and GNA15

Number of citations of the paper that reports this interaction (PubMedID 9742207)
38

Data Source:
HPRD (in vitro, in vivo)

		LTB4R	GNA15
Description		leukotriene B4 receptor	G protein subunit alpha 15
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	Nucleotide Binding Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Muscle Contraction Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium-mediated Signaling
Pathways		Leukotriene receptors G alpha (q) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Amelubant Morniflumate Leukotriene B4
Diseases
GWAS		Parent of origin effect on language impairment (paternal) ( 24571439)	Asthma ( 31959851 32296059 34103634) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: GNA15 GNAI2 GRK6 YWHAG	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		1241	2769
HPRD ID		03320	00760
Ensembl ID		ENSG00000213903	ENSG00000060558
Uniprot IDs		Q15722	P30679
PDB IDs		7K15 7VKT
Enriched GO Terms of Interacting Partners?		G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Adaptive Immune Response Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T Cell Costimulation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Activation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Nematode Protein Kinase C Inhibitor Activity Signal Transduction Negative Regulation Of Lymphocyte Activation Beta-adrenergic Receptor Kinase Activity Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Negative Regulation Of Cell Activation Negative Regulation Of Regulatory T Cell Differentiation G Protein-coupled Receptor Kinase Activity Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of T Cell Activation Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Trans-synaptic Signaling Synaptic Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Cell-cell Signaling G Protein-coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of MAPK Cascade Cell Communication G Protein-coupled Opioid Receptor Activity Regulation Of System Process Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Muscle System Process Postsynaptic Signal Transduction Regulation Of Biological Quality Glutamate Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Dendrite Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Modulation Of Chemical Synaptic Transmission Membrane Chemical Synaptic Transmission Regulation Of Muscle Contraction Cannabinoid Receptor Activity Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Negative Regulation Of Muscle Contraction Regulation Of Amine Transport Neuronal Dense Core Vesicle Regulation Of Transport Neuropeptide Binding Synapse Cannabinoid Signaling Pathway Interleukin-8 Binding G-protein Alpha-subunit Binding Presynapse Neuropeptide Signaling Pathway
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