GRK5 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 11504827)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, in vitro)

		GRK5	TBXA2R
Description		G protein-coupled receptor kinase 5	thromboxane A2 receptor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs			Ridogrel Seratrodast Morniflumate
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15
Entrez ID		2869	6915
HPRD ID		02926	01768
Ensembl ID		ENSG00000198873	ENSG00000006638
Uniprot IDs		P34947	P21731 Q05C92 Q0VAB0
PDB IDs		4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ	8XJN 8XJO
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior	Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH
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