GRK5 and RCVRN

Number of citations of the paper that reports this interaction (PubMedID 12507501)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRK5	RCVRN
Description		G protein-coupled receptor kinase 5	recoverin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Dendrite Cell Projection Perikaryon
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Regulation Of Calcium Ion Transport
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Myristic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	11 interacting genes: CAV1 GIT2 GRK1 GRK2 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		2869	5957
HPRD ID		02926	01558
Ensembl ID		ENSG00000198873	ENSG00000109047
Uniprot IDs		P34947	P35243
PDB IDs		4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ	2D8N
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Gastrulation Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Protein Kinase Activity Animal Organ Development Regulation Of Signal Transduction Kinase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Double-stranded DNA Binding G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Release Of Cytochrome C From Mitochondria RRNA Transcription Regulation Of The Force Of Heart Contraction ATP Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Negative Regulation Of Fibroblast Proliferation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Death Programmed Cell Death Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Programmed Necrotic Cell Death Signal Transduction Fibroblast Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Inward Rectifier Potassium Channel Inhibitor Activity Leukocyte Activation Somitogenesis Segmentation Negative Regulation Of Lung Blood Pressure In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Chordate Embryonic Development Nuclear Mineralocorticoid Receptor Binding Transcription Coactivator Binding Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis
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