GRK5 and AVPR1B

Number of citations of the paper that reports this interaction (PubMedID 10858434)
0

Data Source:
HPRD (in vitro, in vivo)

		GRK5	AVPR1B
Description		G protein-coupled receptor kinase 5	arginine vasopressin receptor 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane	Endosome Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Arachidonate Secretion Transport Across Blood-brain Barrier
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs			Desmopressin Vasopressin Terlipressin PH-284 SR 121463 Atosiban Lypressin
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	2 interacting genes: AVP GRK5
Entrez ID		2869	553
HPRD ID		02926	02600
Ensembl ID		ENSG00000198873	ENSG00000198049
Uniprot IDs		P34947	P47901
PDB IDs		4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior	V1A Vasopressin Receptor Binding Regulation Of Female Receptivity Renal Water Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cellular PH Reduction Renal Water Absorption Negative Regulation Of Female Receptivity Female Mating Behavior Neurohypophyseal Hormone Activity Aggressive Behavior Protein Kinase Activity Negative Regulation Of Transmission Of Nerve Impulse Response To 2,3,7,8-tetrachlorodibenzodioxine V1B Vasopressin Receptor Binding Maternal Aggressive Behavior Tachykinin Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Glutamate Secretion Regulation Of Prostaglandin Biosynthetic Process Maternal Behavior Grooming Behavior Parental Behavior Positive Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Regulation Of Glutamate Secretion Response To Salt Stress Mating Behavior Neuronal Dense Core Vesicle Negative Regulation Of Apoptotic Process Positive Regulation Of Amino Acid Transport Negative Regulation Of Programmed Cell Death Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Cell Population Proliferation Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Vasoconstriction Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Vasoconstriction Reproductive Behavior Fluid Transport Response To Electrical Stimulus Positive Regulation Of Fatty Acid Metabolic Process Response To Testosterone Renal Absorption
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