GRK5 and AVPR1B

Number of citations of the paper that reports this interaction (PMID 10858434)
10

Data Source:
HPRD (in vitro, in vivo)

		GRK5	AVPR1B
Gene Name		G protein-coupled receptor kinase 5	arginine vasopressin receptor 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Vasopressin Receptor Activity Protein Kinase C Binding Peptide Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Regulation Of Systemic Arterial Blood Pressure By Vasopressin G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Hormone Stimulus Positive Regulation Of Vasoconstriction Response To Peptide
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Desmopressin Vasopressin Terlipressin
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	2 interactors: AVP GRK5
Entrez ID		2869	553
HPRD ID		02926	02600
Ensembl ID		ENSG00000198873
Uniprot IDs		P34947	P47901
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Negative Regulation Of Transmission Of Nerve Impulse Maternal Aggressive Behavior Positive Regulation Of Cellular PH Reduction Penile Erection Positive Regulation Of Glutamate Secretion Positive Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Female Receptivity Hyperosmotic Salinity Response Tachykinin Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Regulation Of Transmission Of Nerve Impulse Aggressive Behavior Sodium-independent Organic Anion Transport Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Glutamate Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Neurological System Process Regulation Of Female Receptivity Maternal Behavior Female Mating Behavior ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Grooming Behavior Apoptotic Process Negative Regulation Of Cell Death Regulation Of Renal Sodium Excretion Copulation Programmed Cell Death Hyperosmotic Response Regulation Of Excretion Cell Death Death Negative Regulation Of Signal Transduction Protein Kinase C Signaling Renal Water Homeostasis Negative Regulation Of Signaling Positive Regulation Of Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Vasoconstriction Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Mitochondrion Organization Mating Behavior Response To Salt Stress Protein Phosphorylation Response To Testosterone Positive Regulation Of Blood Pressure Response To Nicotine Social Behavior
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?