GRK5 and DLGAP2

Number of citations of the paper that reports this interaction (PMID 11700307)
8

Data Source:
HPRD (in vitro)

		GRK5	DLGAP2
Gene Name		G protein-coupled receptor kinase 5	discs, large (Drosophila) homolog-associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Neurofilament Postsynaptic Density Cell Junction Postsynaptic Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Protein Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Neuron-neuron Synaptic Transmission
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)	Menarche (age at onset) ( 23599027)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	13 interactors: ADRB1 BZRAP1 DGCR6 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2
Entrez ID		2869	9228
HPRD ID		02926	09258
Ensembl ID		ENSG00000198873	ENSG00000198010
Uniprot IDs		P34947	Q9P1A6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Vocalization Behavior Social Behavior Regulation Of Postsynaptic Membrane Potential Synapse Assembly Learning Or Memory Synaptic Transmission Cognition Regulation Of Synaptic Transmission Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synapse Organization Single-organism Behavior Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Membrane Potential Positive Regulation Of Ion Transmembrane Transport Dendritic Spine Morphogenesis Positive Regulation Of Synaptic Transmission Membrane Depolarization Memory Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Regulation Of Synaptic Plasticity Adult Behavior Exploration Behavior Postsynaptic Membrane Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Ion Transport Regulation Of The Force Of Heart Contraction Neurological System Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signaling Regulation Of Ion Transport Positive Regulation Of Membrane Potential Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Receptor Clustering Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transporter Activity Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Intersection) ?