GRK5 and AVPR1A

Number of citations: 0 (PubMedID 10858434)
Data Source: HPRD (in vitro, in vivo)

		GRK5	AVPR1A
Name		G protein-coupled receptor kinase 5	arginine vasopressin receptor 1A
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane	Endosome Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding V1A Vasopressin Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Cellular Response To Hormone Stimulus Social Behavior Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Transport Across Blood-brain Barrier
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs		None	Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin Pecavaptan
GWAS		Appendicular lean mass ( 33097823 ) Coronary artery aneurysm in Kawasaki disease ( 27171184 ) Early onset periodontitis x smoking status interaction ( 31537151 ) Height ( 28552196 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Methadone dose in opioid dependence ( 30060048 ) Neutrophil percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) Risky sexual behaviors in alcohol dependence ( 28990359 ) Thrombin-induced platelet aggregation ( 32649856 ) Thymus and reactivation regulated chemokine levels ( 33227023 ) Type 2 diabetes ( 22961080 ) Venous thromboembolism ( 31676865 31420334 ) Waist circumference adjusted for body mass index ( 34021172 )	Chronotype ( 30696823 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Hippocampal volume ( 29860282 ) Morning person ( 30696823 ) Type 2 diabetes ( 31049640 )
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	3 interacting genes: AVP GRK5 PRKCA
Entrez ID		2869	552
HPRD ID		02926	02894
Ensembl ID		ENSG00000198873	ENSG00000166148
Uniprot IDs		P34947	P37288 X5D2B0
PDB IDs		4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ	1YTV
GO Terms Enriched among Interactors		Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior	Renal Absorption Protein Kinase Activity Response To Ethanol Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Renal System Process V1B Vasopressin Receptor Binding Regulation Of G Protein-coupled Receptor Signaling Pathway V1A Vasopressin Receptor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Female Receptivity Neurohypophyseal Hormone Activity Response To Ketone Response To Alcohol Maternal Aggressive Behavior Beta-adrenergic Receptor Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Positive Regulation Of Cellular PH Reduction Regulation Of Cell Population Proliferation Positive Regulation Of Secretion By Cell Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Secretion Renal Water Absorption Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Female Receptivity Renal Water Transport Female Mating Behavior Aggressive Behavior Response To 2,3,7,8-tetrachlorodibenzodioxine Tachykinin Receptor Signaling Pathway Protein Phosphorylation G Protein-coupled Receptor Kinase Activity Desmosome Assembly Phosphorylation Signaling Receptor Binding Positive Regulation Of Prostaglandin Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Glutamate Secretion Mitotic Nuclear Membrane Disassembly