GRK5 and AVPR1A

Number of citations of the paper that reports this interaction (PMID 10858434)
10

Data Source:
HPRD (in vivo, in vitro)

		GRK5	AVPR1A
Gene Name		G protein-coupled receptor kinase 5	arginine vasopressin receptor 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding Peptide Hormone Binding V1A Vasopressin Receptor Binding Peptide Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Cellular Response To Hormone Stimulus Social Behavior Positive Regulation Of Renal Sodium Excretion Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Penile Erection Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Response To Peptide
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Desmopressin Vasopressin Felypressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	3 interactors: AVP GRK5 PRKCA
Entrez ID		2869	552
HPRD ID		02926	02894
Ensembl ID		ENSG00000198873
Uniprot IDs		P34947	P37288
PDB IDs			1YTV
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Phosphorylation Histone H3-T6 Phosphorylation Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Cellular Calcium Ion Homeostasis Maternal Aggressive Behavior Positive Regulation Of Cellular PH Reduction Negative Regulation Of Transmission Of Nerve Impulse Penile Erection Calcium Ion Homeostasis Phosphorylation Positive Regulation Of Glutamate Secretion Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Generation Of Precursor Metabolites And Energy Cellular Cation Homeostasis Cellular Ion Homeostasis Negative Regulation Of Female Receptivity Desmosome Assembly Hyperosmotic Salinity Response Tachykinin Receptor Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Glucose Import Positive Regulation Of Amino Acid Transport Positive Regulation Of Macrophage Differentiation Aggressive Behavior Regulation Of Transmission Of Nerve Impulse Sodium-independent Organic Anion Transport
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	aldosterone bdkrb2 caucasians dbsnp functionality genotyped imply infarction infarctions leiden microrna mineralocorticoid myocardial nr3c2 raas renin rs11174811 rs13306046 rs2069591 rs5225 rs5534 smile snp snps targetscan tbxa2r thromboxane twofold vasopressin
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	aldosterone bdkrb2 caucasians dbsnp functionality genotyped imply infarction infarctions leiden microrna mineralocorticoid myocardial nr3c2 raas renin rs11174811 rs13306046 rs2069591 rs5225 rs5534 smile snp snps targetscan tbxa2r thromboxane twofold vasopressin
Tagcloud (Intersection) ?