CAVIN1 and DUX4

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		CAVIN1	DUX4
Description		caveolae associated protein 1	double homeobox 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Membrane Protein-containing Complex Membrane Raft	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	RNA Binding Protein Binding RRNA Binding RRNA Primary Transcript Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Termination Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription RRNA Transcription Protein Secretion Positive Regulation Of Cell Motility	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		RNA Polymerase I Transcription Termination RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: CDC37 CDCA7L DNTTIP2 DUX4 ERCC6 INO80B KAT5 MECOM MRPL45 NKX2-1 OGT SOCS3 SPANXN3 TNFAIP8L1 TSGA10IP TTC5 TTF1 UBC UBE2O YAF2 ZCCHC10 ZFP1 ZNF148 ZSCAN21	124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1
Entrez ID		284119	100288687
HPRD ID		04433
Ensembl ID		ENSG00000177469	ENSG00000260596
Uniprot IDs		Q6NZI2	C3U3A0 Q9UBX2
PDB IDs		9EG6 9EGN 9EIU	5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Circadian Rhythm Positive Regulation Of Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Positive Regulation Of DNA Repair Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H2AK5 Acetyltransferase Activity Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding
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