CAVIN1 and UBE2O

Number of citations of the paper that reports this interaction (PubMedID 36443833)
53

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CAVIN1	UBE2O
Description		caveolae associated protein 1	ubiquitin conjugating enzyme E2 O
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Membrane Protein-containing Complex Membrane Raft	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	RNA Binding Protein Binding RRNA Binding RRNA Primary Transcript Binding Identical Protein Binding	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA-templated Transcription Termination Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription RRNA Transcription Protein Secretion Positive Regulation Of Cell Motility	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination
Pathways		RNA Polymerase I Transcription Termination RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: CDC37 CDCA7L DNTTIP2 DUX4 ERCC6 INO80B KAT5 MECOM MRPL45 NKX2-1 OGT SOCS3 SPANXN3 TNFAIP8L1 TSGA10IP TTC5 TTF1 UBC UBE2O YAF2 ZCCHC10 ZFP1 ZNF148 ZSCAN21	23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3
Entrez ID		284119	63893
HPRD ID		04433	10928
Ensembl ID		ENSG00000177469	ENSG00000175931
Uniprot IDs		Q6NZI2	Q9C0C9
PDB IDs		9EG6 9EGN 9EIU	7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Circadian Rhythm Positive Regulation Of Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Positive Regulation Of DNA Repair Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H2AK5 Acetyltransferase Activity Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane
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