DUX4 and MTHFD1

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DUX4	MTHFD1
Description		double homeobox 4	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane	Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Catalytic Activity Formate-tetrahydrofolate Ligase Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding Oxidoreductase Activity Hydrolase Activity Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Neutrophil Homeostasis Neural Tube Closure Purine Nucleotide Biosynthetic Process Methionine Metabolic Process One-carbon Metabolic Process Heart Development Serine Family Amino Acid Metabolic Process Methionine Biosynthetic Process Purine Ribonucleotide Biosynthetic Process 10-formyltetrahydrofolate Biosynthetic Process Transsulfuration Tetrahydrofolate Interconversion Folic Acid Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Somite Development
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)	Metabolism of folate and pterines
Drugs			Tetrahydrofolic acid NADH LY374571 Nicotinamide adenine dinucleotide phosphate LY249543
Diseases			Spina bifida
GWAS			Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive performance ( 19734545) Longevity ( 30294719) Lymphocyte count ( 27863252)
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	5 interacting genes: CEBPA DUX4 ESR1 SENP3 SUMO2
Entrez ID		100288687	4522
HPRD ID			01403
Ensembl ID		ENSG00000260596	ENSG00000100714
Uniprot IDs		C3U3A0 Q9UBX2	F5H2F4 P11586
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82	1A4I 1DIA 1DIB 1DIG 6ECP 6ECQ 6ECR 9ISE 9ISL 9ISR 9ITD 9IUO
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 Positive Regulation Of RNA Metabolic Process C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process White Fat Cell Proliferation Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Proteolysis Nucleolus Response To Phenylpropanoid Regulation Of Primary Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Steroid Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Branching Involved In Prostate Gland Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation DeSUMOylase Activity Negative Regulation Of G0 To G1 Transition Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Fat Cell Proliferation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Protein Desumoylation
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