DUX4 and VDAC2

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DUX4	VDAC2
Description		double homeobox 4	voltage dependent anion channel 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Sperm Midpiece
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Phospholipid Scramblase Activity Phosphatidylcholine Binding Ceramide Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Binding Of Sperm To Zona Pellucida Plasma Membrane Phospholipid Scrambling Phospholipid Translocation Transmembrane Transport Mitochondrial Outer Membrane Permeabilization Monoatomic Anion Transmembrane Transport Mitochondrial Transmembrane Transport
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)	PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Mitochondrial calcium ion transport
Drugs			Aluminium monostearate PRLX 93936
Diseases
GWAS
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	12 interacting genes: ADRB2 APP BAK1 CFTR CYCS DUX4 DUX4L9 ECT2 HK1 NEDD4 NEDD4L RPS3A
Entrez ID		100288687	7417
HPRD ID			01904
Ensembl ID		ENSG00000260596	ENSG00000165637
Uniprot IDs		C3U3A0 Q9UBX2	A0A024QZT0 B4DKM5 P45880
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82	9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding	Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Transport Regulation Of Sodium Ion Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Protein-folding Chaperone Binding Positive Regulation Of CAMP/PKA Signal Transduction Receptor Catabolic Process Neuronal Dense Core Vesicle Transmembrane Transporter Binding Negative Regulation Of Potassium Ion Transmembrane Transport Enzyme Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Endocytosis Ionotropic Glutamate Receptor Signaling Pathway Receptor-mediated Endocytosis Cell Junction Organization Response To Radiation Cellular Response To Radiation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Macromolecule Metabolic Process Neuromuscular Junction Development Cytosol Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Chemical Homeostasis Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of CAMP/PKA Signal Transduction Import Into Cell Positive Regulation Of Cell Communication Glutamate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential
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