DUX4 and DHX30

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DUX4	DHX30
Description		double homeobox 4	DExH-box helicase 30
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Ribonucleoprotein Granule Mitochondrial Nucleoid
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Helicase Activity Chromatin Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Central Nervous System Development Ribosome Biogenesis Mitochondrial Large Ribosomal Subunit Assembly
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	23 interacting genes: CDK9 CFTR DHX58 DUX4 HDAC1 HDAC3 HNRNPD HSPA13 MYBBP1A NCOR1 NEDD4 NEIL3 NR2E3 OAS3 OGT PRPF39 RBBP4 RBBP7 RBL1 SIN3A SKIL TBL3 USP7
Entrez ID		100288687	22907
HPRD ID			13142
Ensembl ID		ENSG00000260596	ENSG00000132153
Uniprot IDs		C3U3A0 Q9UBX2	H7BXY3 Q7L2E3
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82	2DB2
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding	Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Nucleus Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Histone Deacetylase Binding NuRD Complex Regulation Of Gene Expression Transcription Repressor Complex Chromatin Remodeling Response To Stress Circadian Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Cell Fate Specification Protein Lysine Delactylase Activity Positive Regulation Of Metabolic Process Transcription Corepressor Activity Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity
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