DUX4 and SLC25A5

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DUX4	SLC25A5
Description		double homeobox 4	solute carrier family 25 member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Membrane Mitochondrial Nucleoid MMXD Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Adenine Nucleotide Transmembrane Transporter Activity RNA Binding ATP:ADP Antiporter Activity Protein Binding Proton Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Antiporter Activity Oxidative Phosphorylation Uncoupler Activity Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Chromosome Segregation Positive Regulation Of Cell Population Proliferation Adenine Transport B Cell Differentiation Erythrocyte Differentiation Regulation Of Mitochondrial Membrane Permeability Adenine Nucleotide Transport Transmembrane Transport Mitochondrial ADP Transmembrane Transport Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Proton Transmembrane Transport Mitochondrial ATP Transmembrane Transport Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Mitochondrial protein degradation
Drugs			Clodronic acid Etidronic acid
Diseases
GWAS
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	6 interacting genes: CEBPA CKMT1B DUX4 NFKBIA PTEN RNF26
Entrez ID		100288687	292
HPRD ID			02147
Ensembl ID		ENSG00000260596	ENSG00000005022
Uniprot IDs		C3U3A0 Q9UBX2	P05141 Q6NVC0
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding	Notch Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Positive Regulation Of RNA Biosynthetic Process Response To Tumor Necrosis Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II I-kappaB/NF-kappaB Complex Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Proteolysis Negative Regulation Of Cell Population Proliferation Regulation Of Defense Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development White Fat Cell Proliferation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Inflammatory Response Rb-E2F Complex Phosphocreatine Biosynthetic Process Creatine Kinase Activity Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Developmental Maturation Intracellular Signaling Cassette Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phenylpropanoid Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly
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