CAVIN1 and NKX2-1

Number of citations of the paper that reports this interaction (PubMedID 9582279)
35

Data Source:
BioGRID (pull down)

		CAVIN1	NKX2-1
Description		caveolae associated protein 1	NK2 homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Membrane Protein-containing Complex Membrane Raft	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Binding Protein Binding RRNA Binding RRNA Primary Transcript Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA-templated Transcription Termination Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription RRNA Transcription Protein Secretion Positive Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Pattern Specification Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Hypothalamus Development Forebrain Neuron Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex Neuron Differentiation Pituitary Gland Development Telencephalon Cell Migration Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation GABAergic Neuron Differentiation Interneuron Migration
Pathways		RNA Polymerase I Transcription Termination RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases			Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS			Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)
Interacting Genes		24 interacting genes: CDC37 CDCA7L DNTTIP2 DUX4 ERCC6 INO80B KAT5 MECOM MRPL45 NKX2-1 OGT SOCS3 SPANXN3 TNFAIP8L1 TSGA10IP TTC5 TTF1 UBC UBE2O YAF2 ZCCHC10 ZFP1 ZNF148 ZSCAN21	15 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1
Entrez ID		284119	7080
HPRD ID		04433	02798
Ensembl ID		ENSG00000177469	ENSG00000136352
Uniprot IDs		Q6NZI2	P43699
PDB IDs		9EG6 9EGN 9EIU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Circadian Rhythm Positive Regulation Of Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Positive Regulation Of DNA Repair Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H2AK5 Acetyltransferase Activity Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Cellular Response To Hormone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Estradiol Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Transcription Coregulator Activity Anatomical Structure Morphogenesis Chromatin Gland Development Chromatin Binding Transcription Coactivator Binding Protein-containing Complex Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Intracellular Signal Transduction Response To Hormone Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity DNA-templated Transcription Lung Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cell Differentiation Thyroid Gland Development
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