PTRF and NKX2-1

Number of citations of the paper that reports this interaction (PMID 9582279)
32

Data Source:
BioGRID (pull down)

		PTRF	NKX2-1
Gene Name		polymerase I and transcript release factor	NK2 homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Intracellular Membrane-bounded Organelle Protein Complex	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding RRNA Primary Transcript Binding Poly(A) RNA Binding	Core Promoter Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Clara Cell Differentiation Type II Pneumocyte Differentiation
Pathways		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Height ( 18391950) Menarche (age at onset) ( 23667675) Thyroid cancer ( 19198613)
Protein-Protein Interactions		3 interactors: NKX2-1 TTF1 ZNF148	14 interactors: CALR CREBBP GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 PTRF RARA RELA TDG WWTR1
Entrez ID		284119	7080
HPRD ID		04433	02798
Ensembl ID		ENSG00000177469	ENSG00000136352
Uniprot IDs		Q6NZI2	P43699
PDB IDs
Enriched GO Terms of Interacting Partners?		Neural Nucleus Development Globus Pallidus Development Type II Pneumocyte Differentiation Clara Cell Differentiation Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex GABAergic Interneuron Differentiation Lung Secretory Cell Differentiation GABAergic Neuron Differentiation Lung Saccule Development Positive Regulation Of Circadian Rhythm Forebrain Neuron Fate Commitment Leydig Cell Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Forebrain Regionalization Thyroid Gland Development Cerebral Cortex Neuron Differentiation Negative Regulation Of Stem Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Induction Lung Alveolus Development Pituitary Gland Development Regulation Of Epithelial To Mesenchymal Transition Lung Epithelial Cell Differentiation Forebrain Neuron Differentiation Lung Cell Differentiation Lung Morphogenesis Lung Epithelium Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hippocampus Development Oligodendrocyte Differentiation Forebrain Generation Of Neurons Neuron Fate Commitment Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Endoderm Development Head Development Cerebral Cortex Cell Migration Diencephalon Development Regulation Of Circadian Rhythm Transcription From RNA Polymerase II Promoter Limbic System Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Central Nervous System Development Dorsal/ventral Pattern Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Receptor Signaling Pathway Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Gland Development Response To Organic Substance Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Morphogenesis Embryonic Morphogenesis Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Tissue Development Anatomical Structure Morphogenesis Response To Estrogen Regulation Of Metabolic Process Response To Steroid Hormone Positive Regulation Of Cell Proliferation
Tagcloud ?		aggressiveness angiogenesis angiogenic caveola caveolae caveolin cavin conditioned densities du145 ecs ectopic ex experimentally exploited lncap lymphangiogenesis lymphatic manipulated namely orthotopic pc3 prostate secreted specialized subdomains trafficking transcript vessel
Tagcloud (Difference) ?		aggressiveness angiogenesis angiogenic caveola caveolae caveolin cavin conditioned densities du145 ecs ectopic ex experimentally exploited lncap lymphangiogenesis lymphatic manipulated namely orthotopic pc3 prostate secreted specialized subdomains trafficking transcript vessel
Tagcloud (Intersection) ?