DUX4 and RPL22

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DUX4	RPL22
Description		double homeobox 4	ribosomal protein L22
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Cytoplasmic Translation Translation Alpha-beta T Cell Differentiation Translation At Presynapse
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) TPE interval (resting) ( 32386560)
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	27 interacting genes: AP2M1 BAG4 BEND7 CALM1 CDC42 CSE1L CT45A1 DDIT4L DUX4 FGF11 FOXP1 H2BC15 IL7R MAPK14 MDM2 NSFL1C OGT PTEN SDCBP SDCBP2 SLC26A4-AS1 SNCA SRPK2 STAC3 SURF6 THAP1 ZCCHC10
Entrez ID		100288687	6146
HPRD ID			01602
Ensembl ID		ENSG00000260596	ENSG00000116251
Uniprot IDs		C3U3A0 Q9UBX2	P35268
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding	Lipid Binding Regulation Of Cell Cycle Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Presynaptic Endocytosis Positive Regulation Of Cell Population Proliferation Regulation Of Protein Localization Nucleoplasm Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Cycle Process Regulation Of Endocytosis Regulation Of Cell Population Proliferation Cellular Component Assembly Response To Cytokine Response To Peptide Regulation Of Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Transport Cytosol Response To Magnesium Ion Dendritic Spine Morphogenesis Vesicle-mediated Transport In Synapse Regulation Of Organ Growth Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Response To Type II Interferon Regulation Of Transport Regulation Of Cellular Component Size Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Communication Nucleus Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Adhesion Dendritic Spine Organization Regulation Of Synapse Organization Negative Regulation Of Protein-containing Complex Assembly Identical Protein Binding Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Localization Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process
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