UBE2L1 and UBA1

Number of citations of the paper that reports this interaction (PubMedID 11807090)
48

Data Source:
BioGRID (enzymatic study)

		UBE2L1	UBA1
Description		ubiquitin conjugating enzyme E2 L1 (pseudogene)	ubiquitin like modifier activating enzyme 1
Image		No pdb structure
GO Annotations	Cellular Component		Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function		Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		3 interacting genes: ANAPC11 CHFR UBA1	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		283556	7317
HPRD ID			02440
Ensembl ID			ENSG00000130985
Uniprot IDs			A0A024R1A3 P22314
PDB IDs			4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Separation Post-translational Protein Modification Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Macromolecule Catabolic Process Proteolysis Regulation Of Reproductive Process Meiotic Spindle Checkpoint Signaling Ubiquitin Activating Enzyme Activity Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Chromosome Organization Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Meiotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Activity Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Cullin-RING Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Protein Branched Polyubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Cullin Family Protein Binding Protein Metabolic Process Desmosome Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Separation Protein K11-linked Ubiquitination Positive Regulation Of Mitotic Nuclear Division Heterochromatin Mitotic G2/M Transition Checkpoint SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
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