UBE2L1 and ANAPC11

Number of citations of the paper that reports this interaction (PubMedID 10922056)
42

Data Source:
BioGRID (pull down)

		UBE2L1	ANAPC11
Description		ubiquitin conjugating enzyme E2 L1 (pseudogene)	anaphase promoting complex subunit 11
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function		G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process		Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: ANAPC11 CHFR UBA1	58 interacting genes: ANAPC10 ANAPC2 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FOXO3 FRS3 FZR1 GPANK1 H2AC4 H2BC3 H3C1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 SPMIP9 TCEANC TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70
Entrez ID		283556	51529
HPRD ID			12452
Ensembl ID			ENSG00000141552
Uniprot IDs			Q9NYG5
PDB IDs			2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Separation Post-translational Protein Modification Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Macromolecule Catabolic Process Proteolysis Regulation Of Reproductive Process Meiotic Spindle Checkpoint Signaling Ubiquitin Activating Enzyme Activity Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Chromosome Organization Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Meiotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Activity Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Cullin-RING Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Protein Branched Polyubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Cullin Family Protein Binding Protein Metabolic Process Desmosome Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Separation Protein K11-linked Ubiquitination Positive Regulation Of Mitotic Nuclear Division Heterochromatin Mitotic G2/M Transition Checkpoint SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization	Protein Polyubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Protein Modification Process Positive Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Proteasomal Protein Catabolic Process Intermediate Filament Macromolecule Catabolic Process Proteolysis Free Ubiquitin Chain Polymerization Regulation Of Sister Chromatid Segregation Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-protein Transferase Activity Cell Division Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Regulation Of Chromosome Separation Protein Catabolic Process Regulation Of Nuclear Division Protein Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Reproductive Process Positive Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation
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