UBE2L1 and CHFR

Number of citations of the paper that reports this interaction (PubMedID 11807090)
48

Data Source:
BioGRID (pull down)

		UBE2L1	CHFR
Description		ubiquitin conjugating enzyme E2 L1 (pseudogene)	checkpoint with forkhead and ring finger domains
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus PML Body
	Molecular Function		Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Checkpoint Signaling Mitotic G2/M Transition Checkpoint Cell Division
Pathways
Drugs
Diseases
GWAS			Cognitive function ( 24684796) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		3 interacting genes: ANAPC11 CHFR UBA1	30 interacting genes: AURKA BRD4 CBLC EEF1G GABBR1 GRB10 GRB14 HDAC1 HDAC2 ITGAE PML RNF125 RNF7 SIRT1 SMARCA4 SMARCB1 SMARCD1 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2L1 UBE2N UBE2W WDR47
Entrez ID		283556	55743
HPRD ID			05552
Ensembl ID			ENSG00000072609
Uniprot IDs			Q96EP1
PDB IDs			1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Separation Post-translational Protein Modification Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Macromolecule Catabolic Process Proteolysis Regulation Of Reproductive Process Meiotic Spindle Checkpoint Signaling Ubiquitin Activating Enzyme Activity Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Chromosome Organization Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Meiotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Activity Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Cell Cycle Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Cullin-RING Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Protein Branched Polyubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Cullin Family Protein Binding Protein Metabolic Process Desmosome Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Separation Protein K11-linked Ubiquitination Positive Regulation Of Mitotic Nuclear Division Heterochromatin Mitotic G2/M Transition Checkpoint SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein Polyubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Proteolysis Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process P53 Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Signal Transduction Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Stem Cell Population Maintenance Host-mediated Perturbation Of Viral Transcription Regulation Of Double-strand Break Repair Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Nucleosomal DNA Binding Positive Regulation Of Double-strand Break Repair Chromatin Remodeling Protein Lysine Deacetylase Activity ATP Binding NpBAF Complex Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity RSC-type Complex Regulation Of DNA Repair NBAF Complex Negative Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Repair Histone Deacetylase Activity Nucleosome Disassembly
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