ADORA1 and EPB41L2

Number of citations of the paper that reports this interaction (PMID 12974671)
9

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ADORA1	EPB41L2
Gene Name		adenosine A1 receptor	erythrocyte membrane protein band 4.1-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Postsynaptic Membrane Presynaptic Active Zone	Nucleus Nucleoplasm Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Extrinsic Component Of Membrane Cell Junction Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Adenosine Receptor Activity G-protein Coupled Receptor Binding Purine Nucleoside Binding Phospholipase C Activity Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity	Actin Binding Structural Molecule Activity PH Domain Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Neurological System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Regulation Of Synaptic Plasticity Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cardiac Muscle Contraction Regulation Of Excitatory Postsynaptic Membrane Potential Relaxation Of Vascular Smooth Muscle Negative Regulation Of Mucus Secretion Apoptotic Signaling Pathway Negative Regulation Of Long Term Synaptic Depression	Cortical Actin Cytoskeleton Organization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide
Diseases
GWAS			Lentiform nucleus volume ( 22903471) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		11 interactors: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8	13 interactors: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ
Entrez ID		134	2037
HPRD ID		00042	09126
Ensembl ID		ENSG00000163485	ENSG00000079819
Uniprot IDs		B7Z1L9 B7Z379 P30542	B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 O60642 Q59FD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Penile Erection Response To Ammonium Ion Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Drug Cellular Response To Catecholamine Stimulus Cytosolic Calcium Ion Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Platelet Activation Behavior Positive Regulation Of Adenylate Cyclase Activity Regulation Of Ion Transport Cell Surface Receptor Signaling Pathway Locomotory Behavior Regulation Of Secretion Positive Regulation Of Signal Transduction Response To Morphine Cell Activation Muscle System Process Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Lung Alveolus Development Cellular Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Regulation Of Synaptic Transmission Positive Regulation Of Catalytic Activity Positive Regulation Of CAMP Biosynthetic Process Aging Negative Regulation Of Synaptic Transmission Response To Organonitrogen Compound Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Positive Regulation Of CAMP Metabolic Process Chemical Homeostasis	Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cognition Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrion Organization System Development Visual Learning Negative Regulation Of Synaptic Transmission Visual Behavior Neuron-neuron Synaptic Transmission Apoptotic Process Positive Regulation Of Intracellular Transport Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Learning Or Memory Regulation Of Dopamine Uptake Involved In Synaptic Transmission Associative Learning Multicellular Organismal Development Regulation Of Mitochondrion Organization Anatomical Structure Development Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Apoptotic Signaling Pathway Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell Prepulse Inhibition Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Long Term Synaptic Depression Regulation Of Synaptic Transmission, Dopaminergic Neuromuscular Process Positive Regulation Of Organelle Organization Learning Regulation Of Signaling Regulation Of Anion Transport Protein Targeting Developmental Process Regulation Of Renal Sodium Excretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Transport Nervous System Development Intracellular Transport Cell-cell Signaling Regulation Of Excretion
Tagcloud ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d
Tagcloud (Difference) ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d
Tagcloud (Intersection) ?