ADORA1

Description		adenosine A1 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Calyx Of Held Synapse Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding G Protein-coupled Receptor Activity Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Response To Purine-containing Compound Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Dephosphorylation G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Vasodilation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Cognition Leukocyte Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Regulation Of Cardiac Muscle Contraction Excitatory Postsynaptic Potential Long-term Synaptic Depression Mucus Secretion Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression
Pathways		Adenosine P1 receptors G alpha (i) signalling events
Drugs		Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases
GWAS		Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059) Asthma (childhood onset) ( 30929738 31036433) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: NEK2
Interacting Genes		12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR
Entrez ID		134
HPRD ID		00042
Ensembl ID		ENSG00000163485
Uniprot IDs		B7Z1L9 B7Z379 P30542
PDB IDs		5N2S 5UEN 6D9H 7LD3 7LD4
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Dendrite G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Regulation Of Secretion Cell Body G Protein-coupled Dopamine Receptor Signaling Pathway Mu-type Opioid Receptor Binding Plasma Membrane G Protein-coupled Serotonin Receptor Binding Regulation Of Secretion By Cell System Process Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Negative Regulation Of Secretion By Cell Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Muscle System Process Regulation Of Hormone Secretion Regulation Of Body Fluid Levels Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway GTPase Activity Cellular Response To Catecholamine Stimulus Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway GTP Binding G Protein-coupled Receptor Activity Regulation Of Insulin Secretion Positive Regulation Of MAPK Cascade Regulation Of Exocytosis Locomotory Behavior Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Muscle Contraction Negative Regulation Of Insulin Secretion Regulation Of Hormone Levels Negative Regulation Of Peptide Secretion
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