ADORA1 and P2RY1

Number of citations of the paper that reports this interaction (PMID 11390975)
38

Data Source:
HPRD (in vivo)

		ADORA1	P2RY1
Gene Name		adenosine A1 receptor	purinergic receptor P2Y, G-protein coupled, 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Postsynaptic Membrane Presynaptic Active Zone	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	G-protein Coupled Adenosine Receptor Activity G-protein Coupled Receptor Binding Purine Nucleoside Binding Phospholipase C Activity Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity	Receptor Activity Protein Binding ATP Binding A1 Adenosine Receptor Binding ADP Binding G-protein Coupled Purinergic Nucleotide Receptor Activity ATP-activated Nucleotide Receptor Activity ADP-activated Nucleotide Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Neurological System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Regulation Of Synaptic Plasticity Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cardiac Muscle Contraction Regulation Of Excitatory Postsynaptic Membrane Potential Relaxation Of Vascular Smooth Muscle Negative Regulation Of Mucus Secretion Apoptotic Signaling Pathway Negative Regulation Of Long Term Synaptic Depression	Positive Regulation Of Protein Phosphorylation Adenosine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Blood Coagulation Response To Mechanical Stimulus Regulation Of Receptor Activity Negative Regulation Of Norepinephrine Secretion Sensory Perception Of Pain Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Vasodilation Eating Behavior Positive Regulation Of Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Negative Regulation Of Binding Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Relaxation Of Muscle
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Signal amplification Metabolic disorders of biological oxidation enzymes GPCR ligand binding P2Y receptors G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502)
Protein-Protein Interactions		11 interactors: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8	3 interactors: ADORA1 SLC9A3R1 SLC9A3R2
Entrez ID		134	5028
HPRD ID		00042	03103
Ensembl ID		ENSG00000163485	ENSG00000169860
Uniprot IDs		B7Z1L9 B7Z379 P30542	P47900
PDB IDs			1Y36
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Penile Erection Response To Ammonium Ion Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Drug Cellular Response To Catecholamine Stimulus Cytosolic Calcium Ion Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Platelet Activation Behavior Positive Regulation Of Adenylate Cyclase Activity Regulation Of Ion Transport Cell Surface Receptor Signaling Pathway Locomotory Behavior Regulation Of Secretion Positive Regulation Of Signal Transduction Response To Morphine Cell Activation Muscle System Process Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Lung Alveolus Development Cellular Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Regulation Of Synaptic Transmission Positive Regulation Of Catalytic Activity Positive Regulation Of CAMP Biosynthetic Process Aging Negative Regulation Of Synaptic Transmission Response To Organonitrogen Compound Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Positive Regulation Of CAMP Metabolic Process Chemical Homeostasis	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Excretion Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Ion Transport Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Long Term Synaptic Depression Renal Phosphate Ion Absorption Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Negative Regulation Of Signaling Negative Regulation Of Cell Migration Negative Regulation Of Mucus Secretion Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Regulation Of Long Term Synaptic Depression Regulation Of Intracellular Signal Transduction Renal Sodium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glutamate Secretion Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Transport Negative Regulation Of Vasodilation Negative Regulation Of Striated Muscle Contraction Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Intracellular Signal Transduction Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Relaxation Of Vascular Smooth Muscle Bile Acid Secretion Relaxation Of Smooth Muscle Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Regulation Of Glutamate Secretion Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Regulation Of Glomerular Filtration
Tagcloud ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx1 p2rx7 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Difference) ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx1 p2rx7 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Intersection) ?