ADORA1 and DRD1

Number of citations of the paper that reports this interaction (PMID 10890919)
49

Data Source:
HPRD (in vivo)

		ADORA1	DRD1
Gene Name		adenosine A1 receptor	dopamine receptor D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Postsynaptic Membrane Presynaptic Active Zone	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Adenosine Receptor Activity G-protein Coupled Receptor Binding Purine Nucleoside Binding Phospholipase C Activity Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Neurological System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Regulation Of Synaptic Plasticity Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cardiac Muscle Contraction Regulation Of Excitatory Postsynaptic Membrane Potential Relaxation Of Vascular Smooth Muscle Negative Regulation Of Mucus Secretion Apoptotic Signaling Pathway Negative Regulation Of Long Term Synaptic Depression	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synapse Assembly Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Positive Regulation Of CAMP Biosynthetic Process Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide	Ziprasidone Cabergoline Ropinirole Olanzapine Methylergonovine Clozapine Thiethylperazine Phenylpropanolamine Loxapine Pramipexole Promazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lisuride Fluphenazine Thioridazine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupenthixol Dopamine Carphenazine Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Dihydroergotoxine Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Asenapine
Diseases
GWAS			Obesity-related traits ( 23251661) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		11 interactors: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8	11 interactors: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 EPB41L2 FLNA GRIN1 HRH3
Entrez ID		134	1812
HPRD ID		00042	00538
Ensembl ID		ENSG00000163485	ENSG00000184845
Uniprot IDs		B7Z1L9 B7Z379 P30542	P21728
PDB IDs			1OZ5
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Penile Erection Response To Ammonium Ion Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Drug Cellular Response To Catecholamine Stimulus Cytosolic Calcium Ion Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Platelet Activation Behavior Positive Regulation Of Adenylate Cyclase Activity Regulation Of Ion Transport Cell Surface Receptor Signaling Pathway Locomotory Behavior Regulation Of Secretion Positive Regulation Of Signal Transduction Response To Morphine Cell Activation Muscle System Process Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Lung Alveolus Development Cellular Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Regulation Of Synaptic Transmission Positive Regulation Of Catalytic Activity Positive Regulation Of CAMP Biosynthetic Process Aging Negative Regulation Of Synaptic Transmission Response To Organonitrogen Compound Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Positive Regulation Of CAMP Metabolic Process Chemical Homeostasis	Negative Regulation Of Mucus Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Transport Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Glutamate Secretion Vesicle-mediated Transport Negative Regulation Of Transport Membrane Organization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Mucus Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Circadian Rhythm Negative Regulation Of Leukocyte Migration Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Secretion Vesicle Organization Dopamine Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To ER Response To Morphine Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Cognition Establishment Of Protein Localization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Deoxyadenosine Catabolic Process Positive Regulation Of Nucleoside Transport Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Propylene Metabolic Process Xanthine Biosynthetic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Budding Sensory Perception Of Pain Response To Ammonium Ion Protein Complex Assembly Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Feeding Behavior Olfactory Learning Negative Regulation Of Gamma-aminobutyric Acid Secretion Purine Deoxyribonucleoside Metabolic Process Protein Localization Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell
Tagcloud ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Difference) ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Intersection) ?