RGS19 and OSTM1

Number of citations of the paper that reports this interaction (PubMedID 12826607)
47

Data Source:
HPRD (two hybrid, in vitro)

		RGS19	OSTM1
Description		regulator of G protein signaling 19	osteoclastogenesis associated transmembrane protein 1
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Lysosome Lysosomal Membrane Cytosol Membrane Chloride Channel Complex
	Molecular Function	GTPase Activity Protein Binding	Protein Binding
	Biological Process	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Negative Regulation Of Signal Transduction	Osteoclast Differentiation Transepithelial Chloride Transport
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)	Major depressive disorder ( 29187746) Psoriasis ( 31376382)
Interacting Genes		26 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HINT1 HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN	7 interacting genes: CFTR CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Entrez ID		10287	28962
HPRD ID		05461	09628
Ensembl ID		ENSG00000171700	ENSG00000081087
Uniprot IDs		B4DP94 P49795	A0A8V8TNX7 A0A8V8TPT7 Q86WC4
PDB IDs		1CMZ	7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide Binding G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Protein Kinase CK2 Complex G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Protein Serine/threonine Kinase Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Outer Ear Morphogenesis Protein Kinase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Ciliary Basal Body Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Insulin Secretion Negative Regulation Of Secretion Negative Regulation Of Hormone Secretion Protein Serine Kinase Activity GTP Binding Negative Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Body Kinase Activity MAP Kinase Activity Apoptotic Process Cell Death Signal Transduction Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transforming Growth Factor Beta Binding Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Plasma Membrane PcG Protein Complex Negative Regulation Of Protein Catabolic Process	Chloride Transmembrane Transporter Activity Transepithelial Transport Chloride Channel Complex Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency GTPase Activity Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Chloride Transmembrane Transport Inorganic Anion Transmembrane Transport Chloride Transport Positive Regulation Of Monoatomic Anion Transport Monoatomic Anion Transport Chloride:proton Antiporter Activity DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Transepithelial Water Transport Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Tooth Mineralization Nucleotide-excision Repair, DNA Gap Filling Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA-dependent Protein Kinase-DNA Ligase 4 Complex G Protein-coupled Receptor Signaling Pathway Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transepithelial Chloride Transport Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair GTPase Activator Activity Lymphoid Progenitor Cell Differentiation AMP Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport
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