RGS19 and KRTAP5-6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RGS19	KRTAP5-6
Description		regulator of G protein signaling 19	keratin associated protein 5-6
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Cytosol Intermediate Filament
	Molecular Function	GTPase Activity Protein Binding	Protein Binding
	Biological Process	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Negative Regulation Of Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Keratinization
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
Interacting Genes		26 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HINT1 HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN	93 interacting genes: ADAM12 ADAMTSL4 CATSPER1 CCN3 COL8A1 CRCT1 CREB5 CYSRT1 DDIT4L GLRX3 GUCD1 HOXA1 INCA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP13-3 KRTAP17-1 KRTAP26-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LBX1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 MAPKBP1 MEOX2 MYPOP NBPF19 NLK NOTCH2NLA NOTO NR1D2 NR4A3 NUFIP2 OTX1 OXER1 PLSCR1 POU4F2 RGS17 RGS19 RGS20 SMCP SPRY2 TRIM42 VASN VGLL3 YY1
Entrez ID		10287	440023
HPRD ID		05461	17250
Ensembl ID		ENSG00000171700	ENSG00000205864
Uniprot IDs		B4DP94 P49795	Q6L8G9
PDB IDs		1CMZ
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide Binding G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Protein Kinase CK2 Complex G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Protein Serine/threonine Kinase Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Outer Ear Morphogenesis Protein Kinase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Ciliary Basal Body Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Insulin Secretion Negative Regulation Of Secretion Negative Regulation Of Hormone Secretion Protein Serine Kinase Activity GTP Binding Negative Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Body Kinase Activity MAP Kinase Activity Apoptotic Process Cell Death Signal Transduction Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transforming Growth Factor Beta Binding Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Plasma Membrane PcG Protein Complex Negative Regulation Of Protein Catabolic Process	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Cytosol
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