RGS19 and OPRL1

Number of citations of the paper that reports this interaction (PubMedID 11090272)
0

Data Source:
HPRD (in vitro, in vivo)

		RGS19	OPRL1
Description		regulator of G protein signaling 19	opioid related nociceptin receptor 1
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane
	Molecular Function	GTPase Activity Protein Binding	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding
	Biological Process	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Negative Regulation Of Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)	A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HINT1 HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN	10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
Entrez ID		10287	4987
HPRD ID		05461	03971
Ensembl ID		ENSG00000171700	ENSG00000125510
Uniprot IDs		B4DP94 P49795	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs		1CMZ	4EA3 5DHG 5DHH 8F7X
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide Binding G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Protein Kinase CK2 Complex G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Protein Serine/threonine Kinase Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Outer Ear Morphogenesis Protein Kinase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Ciliary Basal Body Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Insulin Secretion Negative Regulation Of Secretion Negative Regulation Of Hormone Secretion Protein Serine Kinase Activity GTP Binding Negative Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Body Kinase Activity MAP Kinase Activity Apoptotic Process Cell Death Signal Transduction Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transforming Growth Factor Beta Binding Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Plasma Membrane PcG Protein Complex Negative Regulation Of Protein Catabolic Process	Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity
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